The information in this table is for Excipients in Vaccines Routinely Recommended in the US
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| Excipient | Purpose | Vaccine Name | Vaccine Type | Amount per 0.5 mL Dose (unless otherwise noted) |
|---|---|---|---|---|
| Mannitol | Stabilizer | Abrysvo | RSV | 22.5 mg |
| Polysorbate 80 | Surfactant | Abrysvo | RSV | 0.08 mg |
| Salts, Mineral | Adjust tonicity | Abrysvo | RSV | 1.1 mg sodium chloride |
| Sucrose | Stabilizer | Abrysvo | RSV | 11.3 mg |
| Tromethamine | Stabilizer | Abrysvo | RSV | 0.11 mg |
| Tromethamine Hydrochloride | Stabilizer | Abrysvo | RSV | 1.04 mg |
| Ammonium Sulfate | Protein Purifier | ActHIB | Hib | Ingredient in purification |
| Bovine Casein | Medium Nutrient | ActHIB | Hib | Amount not specified in package insert |
| Formaldehyde | Inactivating Agent | ActHIB | Hib | <0.5 mcg |
| Salts, Mineral | Adjust tonicity | ActHIB | Hib | 0.4% sodium chloride in diluent |
| Sucrose | Stabilizer | ActHIB | Hib | 8.5% |
| 2-Phenoxyethanol | Stabilizer | Adacel | Tdap | 3.3 mg (0.6% v/v) (not as a preservative) |
| Aluminum Phosphate | Adjuvant | Adacel | Tdap | 1.5 mg (0.33 mg aluminum) |
| Ammonium Sulfate | Protein Purifier | Adacel | Tdap | Ingredient in purification |
| Bovine, Casamino Acid | Stabilizer | Adacel | Tdap | Amount not specified in package insert |
| Dimethyl-beta-cyclodextrin | Medium Nutrient | Adacel | Tdap | Amount not specified in package insert |
| Formaldehyde | Inactivating Agent | Adacel | Tdap | ≤5 mcg |
| Glutaraldehyde | Inactivating Agent | Adacel | Tdap | <50 ng (residual) |
| Albumin, Egg (Ovalbumin) | Residual Medium | Afluria | Influenza | ≤1 mcg |
| Beta-Propiolactone | Viral Inactivator | Afluria | Influenza | <2.3 ng |
| Calcium Chloride | Medium Nutrient | Afluria | Influenza | 0.5 mcg |
| Hydrocortisone | Medium Nutrient | Afluria | Influenza | ≤0.56 ng |
| Neomycin Sulfate | Antimicrobial | Afluria | Influenza | ≤61.5 ng |
| Phosphate Buffer | Buffer | Afluria | Influenza | 20 mcg monobasic potassium phosphate 80 mcg monobasic sodium phosphate 300 mcg diabasic sodium phosphate |
| Polymyxin B | Antimicrobial | Afluria | Influenza | ≤10.5 ng |
| Potassium Chloride | Buffer | Afluria | Influenza | 20 mcg |
| Salts, Mineral | Adjust tonicity | Afluria | Influenza | 4.1 mg sodium chloride |
| Sodium Taurodeoxycholate | Protein Purifier | Afluria | Influenza | ≤10 ppm (residual) |
| Sucrose | Stabilizer | Afluria | Influenza | <10 mcg |
| Thimerosal | Preservative | Afluria | Influenza | 24.5 mcg mercury only in multi-dose vial; none in single dose |
| AS01E | Adjuvant | AREXVY | RSV | Amount not specified in package insert |
| Cholesterol | Lipid | AREXVY | RSV | 0.125 mg |
| DNA | Residual Medium | AREXVY | RSV | ≤0.80 ng/mg |
| DOPC | Lipid in AS01E | AREXVY | RSV | 0.5 mg |
| Host cell Proteins | Residual medium | AREXVY | RSV | ≤2.0% |
| Phosphate Buffer | Buffer | AREXVY | RSV | 4.4 mg sodium chloride 0.83 mg potassium dihydrogen phosphate 0.26 mg dipotassium phosphate 0.15 mg of disodium phosphate anhydrous |
| Polysorbate 80 | Surfactant | AREXVY | RSV | 0.18 mg |
| Salts, Mineral | Adjust tonicity | AREXVY | RSV | 4.4 mg sodium chloride |
| Trehalose | Stabilizer | AREXVY | RSV | 14.7 mg |
| Aluminum Hydroxide | Adjuvant | Bexsero | Meningococcal B | 1.5 mg (0.519 mg aluminum) |
| Histidine | Medium Nutrient | Bexsero | Meningococcal B | 0.776 mg |
| Kanamycin | Antimicrobial | Bexsero | Meningococcal B | <0.01 mcg |
| Salts, Mineral | Adjust tonicity | Bexsero | Meningococcal B | 3.125 mg sodium chloride |
| Sucrose | Stabilizer | Bexsero | Meningococcal B | 10 mg |
| Aluminum Hydroxide | Adjuvant | Boostrix | Tdap | ≤0.3 mg aluminum |
| Bovine Casein | Medium Nutrient | Boostrix | Tdap | Amount not specified in package insert |
| Bovine Extract | Medium Nutrient | Boostrix | Tdap | Amount not specified in package insert |
| Formaldehyde | Inactivating Agent | Boostrix | Tdap | ≤100 mcg (residual) |
| Glutaraldehyde | Inactivating Agent | Boostrix | Tdap | Amount not specified in package insert |
| Polysorbate 80 | Surfactant | Boostrix | Tdap | ≤100 mcg (Tween 80) |
| Salts, Mineral | Adjust tonicity | Boostrix | Tdap | 4.4 mg sodium chloride |
| Dextrose | Medium Nutrient | Capvaxive | Pneumococcal 21 | Amount not specified in package insert |
| L-histidine | Medium Nutrient | Capvaxive | Pneumococcal 21 | 1.55 mg |
| Phenol | Inactivating agent | Capvaxive | Pneumococcal 21 | Ingredient in purification |
| Polysorbate 20 | Surfactant | Capvaxive | Pneumococcal 21 | 0.50 mg |
| Salts, Mineral | Adjust tonicity | Capvaxive | Pneumococcal 21 | 4.49 mg sodium chloride |
| Yeast | Medium Nutrient | Capvaxive | Pneumococcal 21 | Amount not specified in package insert |
| (4-hydroxybutyl)azanediyl) bis(hexane-6,1-diyl)bis(2-hexyldecanoate) | Lipid | Comirnaty (Pfizer) | COVID-19 | 0.43 mg/0.3 mL dose |
| 1,2-distearoyl-sn-glycero-3-phosphocholine [DSPC]) | Lipid | Comirnaty (Pfizer) | COVID-19 | 0.09 mg/0.3 mL dose |
| Cholesterol | Lipid | Comirnaty (Pfizer) | COVID-19 | 0.19 mg/0.3 mL dose |
| Polyethylene Glycol | Lipid | Comirnaty (Pfizer) | COVID-19 | 0.05 mg 2[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide/0.3 mL dose |
| Sucrose | Stabilizer | Comirnaty (Pfizer) | COVID-19 | 31 ng/0.3 mL dose |
| Tromethamine | Stabilizer | Comirnaty (Pfizer) | COVID-19 | 0.06 mg/0.3 mL dose |
| Tromethamine Hydrochloride | Stabilizer | Comirnaty (Pfizer) | COVID-19 | 0.4 mg/0.3 mL dose |
| 2-Phenoxyethanol | Stabilizer | Daptacel | DTaP | 3.3 mg (0.6% v/v) (not as a preservative) |
| Aluminum Phosphate | Adjuvant | Daptacel | DTaP | 1.5 mg (0.33 mg aluminum) |
| Ammonium Sulfate | Protein Purifier | Daptacel | DTaP | Ingredient in purification |
| Bovine, Casamino Acid | Stabilizer | Daptacel | DTaP | Amount not specified in package insert |
| Dimethyl-beta-cyclodextrin | Medium Nutrient | Daptacel | DTaP | Amount not specified in package insert |
| Formaldehyde | Inactivating Agent | Daptacel | DTaP | ≤5 mcg (residual) |
| Glutaraldehyde | Inactivating Agent | Daptacel | DTaP | <50 ng (residual) |
| Aluminum Phosphate | Adjuvant | DT | DT | 1.5 mg |
| Bovine Casein | Medium Nutrient | DT | DT | Amount not specified in package insert |
| Dextrose | Medium Nutrient | DT | DT | Amount not specified in package insert |
| Formaldehyde | Inactivating Agent | DT | DT | <100 mcg |
| Salts, Inorganic | Medium Nutrient | DT | DT | Sodium chloride – Amount not specified in package insert |
| Vitamins | Medium Nutrient | DT | DT | Ingredient in growth medium |
| Aluminum | Adjuvant | Engerix-B | HepB | 0.5 mg/mL aluminum as aluminum hydroxide |
| Phosphate Buffer | Buffer | Engerix-B | HepB | 0.9 mg/mL Disodium phosphate dihydrate 0.7 mg/mL Sodium dihydrogen phosphate dihydrate |
| Salts, Mineral | Adjust tonicity | Engerix-B | HepB | 8 mg/mL sodium chloride |
| Yeast | Medium Nutrient | Engerix-B | HepB | ≤5% yeast protein |
| Cetyltrimethlyammonium Bromide (CTAB) | Protein Purifier | Fluad | Influenza | ≤12 mcg |
| Citric Acid Monohydrate | Buffer | Fluad | Influenza | 0.04 mg at pH 6.9-7.7 |
| Egg Protein (ovalbumin) | Residual Medium | Fluad | Influenza | <0.4 mcg |
| Formaldehyde | Inactivating Agent | Fluad | Influenza | ≤10 mcg |
| Hydrocortisone | Medium Nutrient | Fluad | Influenza | ≤0.005 ng |
| Kanamycin | Antimicrobial | Fluad | Influenza | ≤0.03 mcg |
| MF59 | Adjuvant | Fluad | Influenza | Amount not specified in package insert |
| Neomycin | Antimicrobial | Fluad | Influenza | ≤0.02 mcg |
| Polysorbate 80 | Surfactant | Fluad | Influenza | 1.175 mg |
| Sodium Citrate Dihydrate | Buffer | Fluad | Influenza | 0.66 mg |
| Sorbitan Trioleate | Stabilizer | Fluad | Influenza | 1.175 mg |
| Squalene | Adjuvant | Fluad | Influenza | 9.75 mg |
| Albumin, Egg (Ovalbumin) | Residual Medium | Fluarix | Influenza | ≤0.05 mcg |
| Formaldehyde | Inactivating Agent | Fluarix | Influenza | ≤5 mcg |
| Gentamicin Sulfate | Antimicrobial | Fluarix | Influenza | ≤0.15 mcg |
| Hydrocortisone | Medium Nutrient | Fluarix | Influenza | ≤0.0015 mcg |
| Octoxynol-10 (Triton X-100) | Surfactant | Fluarix | Influenza | ≤0.085 mg |
| Polysorbate 80 (Tween 80) | Surfactant | Fluarix | Influenza | ≤0.415 mg (Tween 80) |
| Sodium Deoxycholate | Surfactant | Fluarix | Influenza | ≤50 mcg |
| Vitamins | Protein Purifier | Fluarix | Influenza | ≤0.1 mg α-tocopheryl hydrogen succinate |
| Amino Acid | Medium Nutrient | Flublok | Influenza | Ingredient in growth medium |
| DNA | Residual Medium | Flublok | Influenza | ≤10 ng |
| Octoxynol-10 (Triton X-100) | Surfactant | Flublok | Influenza | ≤100 mcg |
| Phosphate Buffer | Buffer | Flublok | Influenza | 0.2 mcg monobasic sodium phosphate 0.5 mg dibasic sodium phosphate |
| Polysorbate 20 | Surfactant | Flublok | Influenza | ≤27.5 mcg (Tween 20) |
| Salts, Mineral | Adjust tonicity | Flublok | Influenza | 4.4 mg sodium chloride |
| Vitamins | Protein Purifier | Flublok | Influenza | Ingredient in growth medium |
| Beta-Propiolactone | Viral Inactivator | Flucelvax | Influenza | <0.5 mcg |
| Cetyltrimethlyammonium Bromide (CTAB) | Protein Purifier | Flucelvax | Influenza | ≤13.5mcg |
| DNA | Residual Medium | Flucelvax | Influenza | ≤10 ng MDCK cell DNA ≤21.6 mcg MDCK cell protein |
| Polysorbate 80 (Tween 80) | Surfactant | Flucelvax | Influenza | ≤1125 mcg (Tween 80) |
| Protein | Residual Medium | Flucelvax | Influenza | ≤ 225 mcg |
| Thimerosal | Preservative | Flucelvax | Influenza | <25 mcg mercury only in multi-dose vial; none in single dose |
| Albumin, Egg (Ovalbumin) | Residual Medium | Flulaval | Influenza | ≤0.3 mcg |
| Formaldehyde | Inactivating Agent | Flulaval | Influenza | ≤25 mcg |
| Polysorbate 80 | Surfactant | Flulaval | Influenza | ≤665 mcg |
| Sodium Deoxycholate | Surfactant | Flulaval | Influenza | ≤50 mcg |
| Vitamins | Protein Purifier | Flulaval | Influenza | ≤240 mcg α-tocopheryl hydrogen succinate |
| Albumin, Egg (Ovalbumin) | Residual Medium | FluMist | Influenza | ≤0.024 mcg/0.2mL dose |
| Arginine | FluMist | Influenza | 2.42 mg/0.2mL dose | |
| Ethylenediaminetetraacetic acid (EDTA) | Preservative | FluMist | Influenza | <2.3 mcg/0.2mL dose |
| Gelatin, Porcine, Hydrolyzed | Stabilizer | FluMist | Influenza | 2.00 mg/0.2 mL dose |
| Gentamicin Sulfate | Antimicrobial | FluMist | Influenza | <0.015 mcg/mL |
| Monosodium glutamate | Stabilizer | FluMist | Influenza | 0.188 mg/0.2 mL dose |
| Phosphate Buffer | Buffer | FluMist | Influenza | 0.96 mg/0.2 mL dose monobasic potassium phosphate 2.26 mg/0.2mL dose dibasic potassium phosphate |
| Sucrose | Stabilizer | FluMist | Influenza | 13.68 mg/0.2 mL dose |
| Albumin, Egg (Ovalbumin) | Residual Medium | Fluvirin | Influenza | ≤1 mcg |
| Beta-Propiolactone | Viral Inactivator | Fluvirin | Influenza | ≤0.5 mcg |
| Neomycin | Antimicrobial | Fluvirin | Influenza | ≤2.5 mcg |
| Nonylphenol Ethoxylate | Surfactant | Fluvirin | Influenza | ≤0.015% w/v |
| Polymyxin | Antimicrobial | Fluvirin | Influenza | ≤3.75 mcg |
| Thimerosal | Preservative | Fluvirin | Influenza | 25 mcg mercury/dose in multi-dose vial; ≤1 mcg/dose mercury in prefilled syringe |
| Formaldehyde | Inactivating Agent | FluZone | Influenza | ≤100 mcg |
| Octylphenol Ethoxylate (Triton X-100) | Surfactant | FluZone | Influenza | ≤150 mcg |
| Phosphate Buffer | Buffer | FluZone | Influenza | Sodium phosphate-buffered isotonic sodium chloride solution – “quantity sufficient to appropriate volume” |
| Thimerosal | Preservative | FluZone | Influenza | 25 mcg mercury in multi-dose vial; none in single dose |
| Formaldehyde | Inactivating Agent | FluZone High-Dose | Influenza | ≤100 mcg |
| Octylphenol Ethoxylate (Triton X-100) | Surfactant | FluZone High-Dose | Influenza | ≤250 mcg |
| Phosphate Buffer | Buffer | FluZone High-Dose | Influenza | Sodium phosphate-buffered isotonic sodium chloride solution – “quantity sufficient to appropriate volume” |
| Aluminum | Adjuvant | Gardasil | HPV | 225 mcg as amorphous aluminum hydroxyphosphate sulfate |
| Amino Acid | Medium Nutrient | Gardasil | HPV | Ingredient in growth medium |
| Carbohydrates | Medium Nutrient | Gardasil | HPV | Amount not specified in package insert |
| L-histidine | Medium Nutrient | Gardasil | HPV | 0.78 mg |
| Polysorbate 80 | Surfactant | Gardasil | HPV | 50 mcg |
| Salts, Mineral | Adjust tonicity | Gardasil | HPV | 9.56 mg sodium chloride |
| Sodium Borate | Buffer | Gardasil | HPV | 35 mcg |
| Vitamins | Medium Nutrient | Gardasil | HPV | Amount not specified in package insert |
| Yeast | Medium Nutrient | Gardasil | HPV | <7 mcg yeast protein |
| Aluminum | Adjuvant | Gardasil 9 | HPV | 500 mcg as amorphous aluminum hydroxyphosphate sulfate |
| Amino Acid | Medium Nutrient | Gardasil 9 | HPV | Amount not specified in package insert |
| Carbohydrates | Medium Nutrient | Gardasil 9 | HPV | Amount not specified in package insert |
| L-histidine | Medium Nutrient | Gardasil 9 | HPV | 0.78 mg |
| Polysorbate 80 | Surfactant | Gardasil 9 | HPV | 50 mcg |
| Salts, Mineral | Adjust tonicity | Gardasil 9 | HPV | 9.56 mg sodium chloride |
| Sodium Borate | Buffer | Gardasil 9 | HPV | 35 mcg |
| Vitamins | Medium Nutrient | Gardasil 9 | HPV | Amount not specified in package insert |
| Yeast | Medium Nutrient | Gardasil 9 | HPV | <7 mcg yeast protein |
| Aluminum | Adjuvant | Havrix | HepA | 0.25 mg (as aluminum hydroxide) |
| Amino Acid | Medium Nutrient | Havrix | HepA | Amino acid supplement – 0.3% w/v |
| Formaldehyde | Inactivating Agent | Havrix | HepA | ≤0.1 mg /mL formalin |
| MRC-5 | Manufacturing Residue | Havrix | HepA | ≤5 mcg/mL |
| Neomycin Sulfate | Antimicrobial | Havrix | HepA | ≤40 ng/mL |
| Polysorbate 20 | Surfactant | Havrix | HepA | 0.05 mg/mL |
| CpG 1018 | Adjuvant | Heplisav-B | HepB | 3000 mcg |
| Deoxycholate | Emulsifier | Heplisav-B | HepB | <0.9 ppm |
| Phosphate Buffer | Buffer | Heplisav-B | HepB | 9.0 mg/mL sodium chloride 1.75 mg/mL sodium phosphate, dibasic dodecahydrate 0.48 mg/mL sodium phosphate, monobasic dihydrate |
| Polysorbate 80 | Surfactant | Heplisav-B | HepB | 0.1 mg/mL |
| Vitamins | Medium Nutrient | Heplisav-B | HepB | Amount not specified in package insert |
| Yeast | Medium Nutrient | Heplisav-B | HepB | Yeast protein: ≤5.0% of total protein (residual) Yeast DNA: <20 pg |
| Formaldehyde | Inactivating Agent | Hiberix | Hib | <0.5 mcg (residual) |
| Lactose | Stabilizer | Hiberix | Hib | 12.6 mg |
| Salts, Mineral | Adjust tonicity | Hiberix | Hib | 0.9% sodium chloride in diluent |
| Aluminum Hydroxide | Adjuvant | Infanrix | DTaP | 0.5 mg aluminum |
| Bovine Casein | Medium Nutrient | Infanrix | DTaP | Amount not specified in package insert |
| Bovine Extract | Stabilizer | Infanrix | DTaP | Amount not specified in package insert |
| Formaldehyde | Inactivating Agent | Infanrix | DTaP | ≤100 mcg (residual) |
| Glutaraldehyde | Inactivating Agent | Infanrix | DTaP | Amount not specified in package insert |
| Polysorbate 80 | Surfactant | Infanrix | DTaP | ≤100 mcg (Tween 80) |
| Salts, Mineral | Adjust tonicity | Infanrix | DTaP | 4.4 mg sodium chloride |
| Albumin, Bovine Serum | Stabilizer | Kinrix | DTaP+IPV | VERO cell culture growth |
| Aluminum Hydroxide | Adjuvant | Kinrix | DTaP+IPV | ≤0.5 mg aluminum |
| Bovine Casein | Medium Nutrient | Kinrix | DTaP+IPV | Amount not specified in package insert |
| Bovine Extract | Stabilizer | Kinrix | DTaP+IPV | Amount not specified in package insert |
| Formaldehyde | Inactivating Agent | Kinrix | DTaP+IPV | ≤100 mcg (residual) |
| Glutaraldehyde | Inactivating Agent | Kinrix | DTaP+IPV | Amount not specified in package insert |
| Lactalbumin Hydrolysate | Medium Nutrient | Kinrix | DTaP+IPV | Ingredient in growth medium |
| Neomycin | Antimicrobial | Kinrix | DTaP+IPV | ≤0.05 ng |
| Polymyxin B | Antimicrobial | Kinrix | DTaP+IPV | ≤0.01 ng |
| Polysorbate 80 | Surfactant | Kinrix | DTaP+IPV | ≤100 mcg (Tween 80) |
| Salts, Mineral | Adjust tonicity | Kinrix | DTaP+IPV | ≤4.4 mg sodium chloride |
| Vero Cells | Growth Medium | Kinrix | DTaP+IPV | Amount not specified in package insert |
| Ammonium Sulfate | Protein Purifier | Menactra | Meningococcal ACYW-135 | Ingredient in purification |
| Bovine Casein | Medium Nutrient | Menactra | Meningococcal ACYW-135 | Amount not specified in package insert |
| Bovine, Casamino Acid | Stabilizer | Menactra | Meningococcal ACYW-135 | Amount not specified in package insert |
| Formaldehyde | Inactivating Agent | Menactra | Meningococcal ACYW-135 | <2.66 mcg |
| Phosphate Buffer | Buffer | Menactra | Meningococcal ACYW-135 | Sodium phosphate buffered isotonic sodium chloride solution; amount not specified |
| Ammonium Sulfate | Protein Purifier | MenQuadfi | Meningococcal ACWY | Ingredient in purification |
| Formaldehyde | Inactivating Agent | MenQuadfi | Meningococcal ACWY | <3 mcg/mL |
| Phosphate Buffer | Buffer | MenQuadfi | Meningococcal ACWY | 1.23mg sodium acetate |
| Salts, Mineral | Adjust tonicity | MenQuadfi | Meningococcal ACWY | 3.35 mg sodium chloride |
| Amino Acid | Medium Nutrient | Menveo | Meningococcal ACYW-135 | Amount not specified in package insert |
| Formaldehyde | Inactivating Agent | Menveo | Meningococcal ACYW-135 | ≤0.30 mcg |
| Yeast | Medium Nutrient | Menveo | Meningococcal ACYW-135 | Amount not specified in package insert |
| Albumin, Bovine Serum | Stabilizer | MMR-II | MMR | <1 ppm |
| Albumin, Human | Diluent/Stabilizer | MMR-II | MMR | ≤0.3 mg |
| Chick Embryo | Residual Medium | MMR-II | MMR | No intact cells (may have trace residual protein) |
| Gelatin, hydrolyzed | Stabilizer | MMR-II | MMR | 14.5 mg |
| Neomycin | Antimicrobial | MMR-II | MMR | 25 mcg |
| Sorbitol | Stabilizer, solvent | MMR-II | MMR | 14.5 mg |
| Sucrose | Stabilizer | MMR-II | MMR | 1.9 mg |
| Albumin, Bovine Serum | Stabilizer | Pediarix | DTaP+HepB+IPV | VERO cell culture growth |
| Aluminum | Adjuvant | Pediarix | DTaP+HepB+IPV | ≤0.7 mg |
| Bovine Casein | Medium Nutrient | Pediarix | DTaP+HepB+IPV | Amount not specified in package insert |
| Bovine Extract | Stabilizer | Pediarix | DTaP+HepB+IPV | Amount not specified in package insert |
| Formaldehyde | Inactivating Agent | Pediarix | DTaP+HepB+IPV | ≤100 mcg (residual) |
| Glutaraldehyde | Inactivating Agent | Pediarix | DTaP+HepB+IPV | Amount not specified in package insert |
| Lactalbumin Hydrolysate | Medium Nutrient | Pediarix | DTaP+HepB+IPV | Ingredient in growth medium |
| Neomycin | Antimicrobial | Pediarix | DTaP+HepB+IPV | ≤0.05 ng |
| Polymyxin B | Antimicrobial | Pediarix | DTaP+HepB+IPV | ≤0.01 ng |
| Polysorbate 80 | Surfactant | Pediarix | DTaP+HepB+IPV | ≤100 mcg (Tween 80) |
| Salts, Mineral | Adjust tonicity | Pediarix | DTaP+HepB+IPV | 4.4 mg sodium chloride |
| Vero Cells | Growth Medium | Pediarix | DTaP+HepB+IPV | Amount not specified in package insert |
| Yeast | Medium Nutrient | Pediarix | DTaP+HepB+IPV | ≤5% yeast protein |
| Aluminum | Adjuvant | PedvaxHIB | Hib+HepB | 225 mcg |
| Amino Acid | Medium Nutrient | PedvaxHIB | Hib+HepB | Amount not specified in package insert |
| Phenol | Preservative | PedvaxHIB | Hib+HepB | Ingredient in purification |
| Salts, Mineral | Adjust tonicity | PedvaxHIB | Hib+HepB | 0.9% sodium chloride |
| Aluminum Phosphate | Adjuvant | Penbraya | Meningococcal ACYW-135 | 0.25 mg aluminum |
| Dextrose | Medium Nutrient | Penbraya | Meningococcal ACYW-135 | Amount not specified in package insert |
| L-histidine | Medium Nutrient | Penbraya | Meningococcal ACYW-135 | 0.78 mg |
| Polysorbate 80 | Surfactant | Penbraya | Meningococcal ACYW-135 | 0.018 mg at pH 6.0 |
| Salts, Mineral | Adjust tonicity | Penbraya | Meningococcal ACYW-135 | 4.65 mg sodium chloride |
| Sucrose | Stabilizer | Penbraya | Meningococcal ACYW-135 | 28 mg |
| Trometamol | Stabilizer | Penbraya | Meningococcal ACYW-135 | 0.097 mg |
| Yeast | Medium Nutrient | Penbraya | Meningococcal ACYW-135 | Amount not specified in package insert |
| 2-Phenoxyethanol | Stabilizer | Pentacel | DTaP+IPV+Hib | 3.3 mg (0.6 v/v) (not as a preservative) |
| Albumin, Bovine Serum | Stabilizer | Pentacel | DTaP+IPV+Hib | ≤10 ng |
| Aluminum Phosphate | Adjuvant | Pentacel | DTaP+IPV+Hib | 1.5 mg (0.33 mg aluminum) |
| Ammonium Sulfate | Protein Purifier | Pentacel | DTaP+IPV+Hib | Ingredient in purification |
| Bovine, Casamino Acid | Stabilizer | Pentacel | DTaP+IPV+Hib | Amount not specified in package insert |
| Dimethyl-beta-cyclodextrin | Medium Nutrient | Pentacel | DTaP+IPV+Hib | Ingredient in Stainer-Scholte medium |
| Formaldehyde | Inactivating Agent | Pentacel | DTaP+IPV+Hib | 2-7 mcg (residual) |
| Glutaraldehyde | Inactivating Agent | Pentacel | DTaP+IPV+Hib | <50 ng (residual) |
| Neomycin | Antimicrobial | Pentacel | DTaP+IPV+Hib | <0.01 pg |
| Polymyxin B | Antimicrobial | Pentacel | DTaP+IPV+Hib | <0.000001 pg |
| Polysorbate 80 | Surfactant | Pentacel | DTaP+IPV+Hib | <8.1 mcg |
| Sucrose | Stabilizer | Pentacel | DTaP+IPV+Hib | 42.5 mg |
| Vero cells | Growth Medium | Pentacel | DTaP+IPV+Hib | Amount not specified in package insert |
| Phenol | Preservative | Pneumovax 23 | Pneumococcal 23 | Saline containing 0.25% phenol |
| Salts, Mineral | Adjust tonicity | Pneumovax 23 | Pneumococcal 23 | Ingredient in isotonic saline solution |
| Albumin, Bovine Serum | Stabilizer | Prehevbrio | HepB | <2.5 ng/mL |
| Aluminum Hydroxide | Adjuvant | Prehevbrio | HepB | 0.5 mg/mL aluminum |
| Amino Acid | Medium Nutrient | Prehevbrio | HepB | Amount not specified in package insert |
| DNA, CHO cell | Residual Medium | Prehevbrio | HepB | ≤10 pg/mL |
| CHO cell proteins | Residual Medium | Prehevbrio | HepB | ≤2.5 ng/mL |
| Formaldehyde | Inactivating Agent | Prehevbrio | HepB | ≤500 ng/mL |
| Phosphate Buffer | Buffer | Prehevbrio | HepB | disodium hydrogen phosphate dodecahydrate,0.38 mg/dose potassium dihydrogen phosphate anhydrous,0.02 mg/dose |
| Potassium Chloride | Buffer | Prehevbrio | HepB | 0.02 mg/mL |
| Salts, Mineral | Adjust tonicity | Prehevbrio | HepB | 8.45 mg/mL sodium chloride |
| Aluminum | Adjuvant | Prevnar 13 | Pneumococcal 13 | 125 mcg |
| Ammonium Sulfate | Protein Purifier | Prevnar 13 | Pneumococcal 13 | Ingredient in purification |
| Bovine, Casamino Acid | Stabilizer | Prevnar 13 | Pneumococcal 13 | Amount not specified in package insert |
| Peptone, Soy | Medium Nutrient | Prevnar 13 | Pneumococcal 13 | Ingredient in growth medium |
| Polysorbate 80 | Surfactant | Prevnar 13 | Pneumococcal 13 | 100 mcg |
| Succinate Buffer | Stabilizer | Prevnar 13 | Pneumococcal 13 | 295 mcg |
| Yeast | Medium Nutrient | Prevnar 13 | Pneumococcal 13 | Ingredient in growth medium |
| Aluminum | Adjuvant | Prevnar 20 | Pneumococcal 20 | 125 mcg as aluminum phosphate |
| Bovine, Casamino Acid | Stabilizer | Prevnar 20 | Pneumococcal 20 | Amount not specified in package insert |
| Peptone, Soy | Medium Nutrient | Prevnar 20 | Pneumococcal 20 | Ingredient in growth medium |
| Polysorbate 80 | Surfactant | Prevnar 20 | Pneumococcal 20 | 100 mcg |
| Salts, Mineral | Adjust tonicity | Prevnar 20 | Pneumococcal 20 | 4.4 mg sodium chloride |
| Succinate Buffer | Stabilizer | Prevnar 20 | Pneumococcal 20 | 294 mcg |
| Yeast | Medium Nutrient | Prevnar 20 | Pneumococcal 20 | Ingredient in growth medium |
| Albumin, Bovine serum | Stabilizer | Priorix | MMR | ≤50 mcg |
| Albumin, Egg (Ovalbumin) | Residual Medium | Priorix | MMR | ≤60 mcg |
| Amino Acid | Medium Nutrient | Priorix | MMR | 9 mg |
| Chick Embryo | Residual Medium | Priorix | MMR | Amount not specified in package insert |
| Lactose | Stabilizer | Priorix | MMR | 32 mg anhydrous lactose |
| Mannitol | Stabilizer | Priorix | MMR | 8 mg |
| MRC-5 | Manufacturing Residue | Priorix | MMR | Amount not specified in package insert |
| Neomycin Sulfate | Antimicrobial | Priorix | MMR | ≤25 mcg |
| Albumin, Bovine serum | Stabilizer | ProQuad | MMRV | ≤0.5 mcg |
| Albumin, Human | Diluent/Stabilizer | ProQuad | MMRV | ≤0.31 mg |
| Chick Embryo | Residual Medium | ProQuad | MMRV | No intact cells (may have trace residual protein) |
| DNA | Residual Medium | ProQuad | MMRV | Residual component of MRC-5 cells |
| Gelatin, hydrolyzed | Stabilizer | ProQuad | MMRV | 11 mg |
| Monosodium L-glutamate | Stabilizer | ProQuad | MMRV | 0.40 mg |
| MRC-5 | Manufacturing Residue | ProQuad | MMRV | Residual |
| Neomycin | Antimicrobial | ProQuad | MMRV | <16 mcg |
| Phosphate Buffer | Buffer | ProQuad | MMRV | 36 mcg potassium phosphate dibasic 72 mcg potassium phosphate monobasic 0.34 mg sodium phosphate dibasic |
| Potassium Chloride | Buffer | ProQuad | MMRV | 60 mcg |
| Salts, Mineral | Adjust tonicity | ProQuad | MMRV | 2.4 mg sodium chloride |
| Sodium Bicarbonate | Buffer | ProQuad | MMRV | 0.17 mg |
| Sorbitol | Stabilizer, solvent | ProQuad | MMRV | 1.8 mg |
| Sucrose | Stabilizer | ProQuad | MMRV | 21 mg |
| 2-Phenoxyethanol | Stabilizer | Quadracel | DTaP+IPV | 3.3 mg (0.6 v/v) (not as a preservative) |
| Albumin, Bovine Serum | Stabilizer | Quadracel | DTaP+IPV | ≤50 ng |
| Aluminum Phosphate | Adjuvant | Quadracel | DTaP+IPV | 1.5 mg (0.33 mg aluminum) |
| Ammonium Sulfate | Protein Purifier | Quadracel | DTaP+IPV | Ingredient in purification |
| Bovine, Casamino Acid | Stabilizer | Quadracel | DTaP+IPV | Amount not specified in package insert |
| Formaldehyde | Inactivating Agent | Quadracel | DTaP+IPV | ≤5 mcg |
| Glutaraldehyde | Inactivating Agent | Quadracel | DTaP+IPV | <50 ng |
| MRC-5 | Manufacturing Residue | Quadracel | DTaP+IPV | Ingredient in growth medium |
| Neomycin | Antimicrobial | Quadracel | DTaP+IPV | <4 pg |
| Polymyxin B Sulfate | Antimicrobial | Quadracel | DTaP+IPV | <4 pg |
| Polysorbate 80 | Surfactant | Quadracel | DTaP+IPV | 10 ppm |
| Aluminum | Adjuvant | Recombivax HB | HepB | 0.5 mg/mL |
| Amino Acid | Medium Nutrient | Recombivax HB | HepB | In fermentation medium |
| Amino Acid | Medium Nutrient | Recombivax HB | HepB | Amount not specified in package insert |
| Dextrose | Medium Nutrient | Recombivax HB | HepB | Ingredient in fermentation medium |
| Formaldehyde | Inactivating Agent | Recombivax HB | HepB | <15 mcg/mL (residual) |
| Peptone, Soy | Medium Nutrient | Recombivax HB | HepB | Ingredient in fermentation medium |
| Potassium Aluminum Sulfate | Adjuvant | Recombivax HB | HepB | Amount not specified in package insert |
| Salts, Mineral | Adjust tonicity | Recombivax HB | HepB | Ingredient in fermentation medium |
| Yeast | Medium Nutrient | Recombivax HB | HepB | <1% yeast protein |
| Amino Acid | Medium Nutrient | Rotarix | Rotavirus | Amount not specified in package insert |
| Calcium Carbonate | Buffer | Rotarix | Rotavirus | Ingredient in diluent – Amount not specified in package insert |
| Calcium Chloride | Medium Nutrient | Rotarix | Rotavirus | Amount not specified in package insert |
| Dextran | Stabilizer | Rotarix | Rotavirus | Amount not specified in package insert |
| D-glucose | Medium Nutrient | Rotarix | Rotavirus | In DMEM (Dulbecco’s Modified Eagle Medium) |
| Ferric (III) Nitrate | Medium Nutrient | Rotarix | Rotavirus | In DMEM (Dulbecco’s Modified Eagle Medium) |
| L-cystine | Medium Nutrient | Rotarix | Rotavirus | Amount not specified in package insert |
| L-tyrosine | Medium Nutrient | Rotarix | Rotavirus | Amount not specified in package insert |
| Magnesium Sulfate | Medium Nutrient | Rotarix | Rotavirus | Amount not specified in package insert |
| Phosphate Buffer | Buffer | Rotarix | Rotavirus | Sodium phosphate in DMEM (medium) |
| Porcine DNA | Residual Medium | Rotarix | Rotavirus | PCV-1 |
| Potassium Chloride | Medium Nutrient | Rotarix | Rotavirus | Ingredient in DMEM medium |
| Salts, Mineral | Adjust tonicity | Rotarix | Rotavirus | In DMEM (Dulbecco’s Modified Eagle Medium) |
| Sodium Pyruvate | Medium Nutrient | Rotarix | Rotavirus | in DMEM (medium) |
| Sorbitol | Stabilizer, solvent | Rotarix | Rotavirus | Amount not specified in package insert |
| Sucrose | Stabilizer | Rotarix | Rotavirus | Amount not specified in package insert |
| Vero Cells | Growth Medium | Rotarix | Rotavirus | Amount not specified in package insert |
| Vitamins | Medium Nutrient | Rotarix | Rotavirus | Amount not specified in package insert |
| Xanthan | Thickening agent | Rotarix | Rotavirus | Ingredient in diluent |
| Albumin, Bovine Serum | Stabilizer | RotaTeq | Rotavirus | Trace amounts |
| DNA | Residual Medium | RotaTeq | Rotavirus | Residual component of manufacturing process |
| Phosphate Buffer | Buffer | RotaTeq | Rotavirus | Sodium phosphate monobasic monohydrate |
| Polysorbate 80 | Surfactant | RotaTeq | Rotavirus | Amount not specified in package insert |
| Sodium Citrate | Adjust pH | RotaTeq | Rotavirus | Amount not specified in package insert |
| Sodium Hydroxide | Adjust pH | RotaTeq | Rotavirus | Amount not specified in package insert |
| Sucrose | Stabilizer | RotaTeq | Rotavirus | Amount not specified in package insert |
| Vero Cells | Growth Medium | RotaTeq | Rotavirus | Amount not specified in package insert |
| Amino Acid | Medium Nutrient | Shingrix | Zoster | Ingredient in growth medium |
| AS01B | Adjuvant | Shingrix | Zoster | Amount not specified in package insert |
| Cholesterol | Lipid | Shingrix | Zoster | 0.25 mg |
| DNA | Residual Medium | Shingrix | Zoster | ≤2.1 pg |
| DOPC | Lipid in AS01 | Shingrix | Zoster | 1 mg |
| Host cell Proteins | Residual Medium | Shingrix | Zoster | ≤3.0% |
| Phosphate Buffer | Buffer | Shingrix | Zoster | 0.54 mg potassium dihydrogen phosphate 0.160 mg sodium dihydrogen phosphate dihydrate 0.15 mg disodium phosphate anhydrous 0.116 mg dipotassium phosphate |
| Polysorbate 80 | Surfactant | Shingrix | Zoster | 0.08 mg |
| Salts, Mineral | Adjust tonicity | Shingrix | Zoster | 4.385 mg sodium chloride |
| Sucrose | Stabilizer | Shingrix | Zoster | 20 mg |
| 1,2-distearoyl-sn-glycero-3-phosphocholine [DSPC]) | Lipid | Spikevax (Moderna) | COVID-19 | Amount not specified in package insert |
| Acetic Acid | Adjust pH | Spikevax (Moderna) | COVID-19 | 0.021 mg |
| Cholesterol | Lipid | Spikevax (Moderna) | COVID-19 | Amount not specified in package insert |
| Phosphate Buffer | Buffer | Spikevax (Moderna) | COVID-19 | 0.10 mg sodium acetate |
| Polyethylene Glycol | Lipid | Spikevax (Moderna) | COVID-19 | 1.01 mg (SM-102, polyethylene glycol [PEG] 2000 dimyristoyl glycerol [DMG] |
| Sucrose | Stabilizer | Spikevax (Moderna) | COVID-19 | 43.5 mg |
| Tromethamine | Stabilizer | Spikevax (Moderna) | COVID-19 | 0.31 mg |
| Tromethamine Hydrochloride | Stabilizer | Spikevax (Moderna) | COVID-19 | 1.2 mg |
| Aluminum | Adjuvant | TDVax | Tetanus+Diphtheria | ≤0.53mg |
| Ammonium Sulfate | Protein Purifier | TDVax | Tetanus+Diphtheria | Ingredient in purification |
| Bovine Extract | Stabilizer | TDVax | Tetanus+Diphtheria | Amount not specified in package insert |
| Formaldehyde | Inactivating Agent | TDVax | Tetanus+Diphtheria | <100 mcg |
| Thimerosal | Manufacturing Residue | TDVax | Tetanus+Diphtheria | ≤0.3 mcg mercury (trace amounts) |
| Aluminum | Adjuvant | Tenivac | Tetanus+Diphtheria | 0.33 mg |
| Ammonium Sulfate | Protein Purifier | Tenivac | Tetanus+Diphtheria | Ingredient in purification |
| Bovine, Casamino Acid | Stabilizer | Tenivac | Tetanus+Diphtheria | Amount not specified in package insert |
| Formaldehyde | Inactivating Agent | Tenivac | Tetanus+Diphtheria | ≤5.0 mcg |
| Salts, Mineral | Adjust tonicity | Tenivac | Tetanus+Diphtheria | Sodium chloride – Amount not specified in package insert |
| Aluminum | Adjuvant | Trumenba | Meningococcal B | 0.25 mg |
| Histidine | Medium Nutrient | Trumenba | Meningococcal B | 10 mM |
| Polysorbate 80 | Surfactant | Trumenba | Meningococcal B | 0.018 mg |
| Aluminum Phosphate and Aluminum Hydroxide | Adjuvant | Twinrix | HepA+HepB | 0.45 mg/mL aluminum |
| Amino Acid | Medium Nutrient | Twinrix | HepA+HepB | Amount not specified in package insert |
| Formaldehyde | Inactivating Agent | Twinrix | HepA+HepB | ≤0.1 mg/mL formalin |
| MRC-5 | Manufacturing Residue | Twinrix | HepA+HepB | ≤2.5 mcg/mL |
| Neomycin Sulfate | Antimicrobial | Twinrix | HepA+HepB | ≤20 ng/mL |
| Phosphate Buffer | Buffer | Twinrix | HepA+HepB | Amount not specified in package insert |
| Polysorbate 20 | Surfactant | Twinrix | HepA+HepB | Amount not specified in package insert |
| Salts, Inorganic | Medium Nutrient | Twinrix | HepA+HepB | Sodium chloride – Amount not specified in package insert |
| Salts, Mineral | Adjust tonicity | Twinrix | HepA+HepB | Aluminum salts – Amount not specified in package insert |
| Yeast | Medium Nutrient | Twinrix | HepA+HepB | ≤5% yeast protein |
| Albumin, Bovine | Stabilizer | Vaqta | HepA | <10-4 mcg |
| Aluminum | Adjuvant | Vaqta | HepA | 0.45 mg/mL as amorphous aluminum hydroxyphosphate sulfate |
| DNA | Residual Medium | Vaqta | HepA | <4 x 10–6 mcg |
| Formaldehyde | Inactivating Agent | Vaqta | HepA | <0.8 mcg |
| MRC-5 | Manufacturing Residue | Vaqta | HepA | Amount not specified in package insert |
| Neomycin | Antimicrobial | Vaqta | HepA | <10 ppb (residual) |
| Salts, Mineral | Adjust tonicity | Vaqta | HepA | 0.9% sodium chloride |
| Sodium Borate | Stabilizer | Vaqta | HepA | 70 mcg/mL |
| Albumin, Bovine Serum | Stabilizer | Varivax | Varicella | Trace amounts |
| DNA | Residual Medium | Varivax | Varicella | Residual component of MRC-5 cells |
| Ethylenediaminetetraacetic acid (EDTA) | Preservative | Varivax | Varicella | Trace amounts |
| Gelatin, hydrolyzed | Stabilizer | Varivax | Varicella | 12.5 mg |
| Monosodium L-glutamate | Stabilizer | Varivax | Varicella | 0.5 mg |
| MRC-5 | Manufacturing Residue | Varivax | Varicella | Residual component |
| Neomycin | Antimicrobial | Varivax | Varicella | Trace amounts |
| Phosphate Buffer | Buffer | Varivax | Varicella | 0.08 mg potassium phosphate monobasic 0.45 mg sodium phosphate dibasic Sodium phosphate monobasic, trace amounts |
| Potassium Chloride | Buffer | Varivax | Varicella | 0.08 mg |
| Salts, Mineral | Adjust tonicity | Varivax | Varicella | |
| Sucrose | Stabilizer | Varivax | Varicella | 25 mg |
| Albumin, Bovine Serum | Stabilizer | Vaxelis | DTaP+IPV+HepB | ≤50 ng |
| Aluminum | Adjuvant | Vaxelis | DTaP+IPV+HepB | 319 mcg aluminum from aluminum salts |
| Amino Acid | Medium Nutrient | Vaxelis | DTaP+IPV+HepB | Amount not specified in package insert |
| Ammonium Sulfate | Protein Purifier | Vaxelis | DTaP+IPV+HepB | Ingredient in purification |
| Ammonium Thiocyanate | Manufacturing residue | Vaxelis | DTaP+IPV+HepB | ≤0.125 mcg |
| Amorphous Aluminum Hydroxyphosphate Sulfate (AAHS) | Adjuvant | Vaxelis | DTaP+IPV+HepB | Amount not specified in package insert |
| Formaldehyde | Inactivating Agent | Vaxelis | DTaP+IPV+HepB | ≤14 mcg |
| Glutaraldehyde | Inactivating Agent | Vaxelis | DTaP+IPV+HepB | 50 ng |
| Neomycin | Antimicrobial | Vaxelis | DTaP+IPV+HepB | <5 ng |
| Polymyxin B Sulfate | Antimicrobial | Vaxelis | DTaP+IPV+HepB | <25 ng |
| Polysorbate 80 | Surfactant | Vaxelis | DTaP+IPV+HepB | <0.0056% |
| Streptomycin sulfate | Manufacturing Residue | Vaxelis | DTaP+IPV+HepB | <200 ng |
| Yeast | Medium Nutrient | Vaxelis | DTaP+IPV+HepB | ≤0.1 mcg |
| Aluminum | Adjuvant | Vaxneuvance | Pneumococcal 15 | 125 mcg aluminum as aluminum phosphate adjuvant |
| Dextrose | Medium Nutrient | Vaxneuvance | Pneumococcal 15 | Amount not specified in package insert |
| L-histidine | Medium Nutrient | Vaxneuvance | Pneumococcal 15 | 1.55 mg |
| Peptone, Soy | Medium Nutrient | Vaxneuvance | Pneumococcal 15 | Amount not specified in package insert |
| Polysorbate 20 | Surfactant | Vaxneuvance | Pneumococcal 15 | 1 mg |
| Salts, Mineral | Adjust tonicity | Vaxneuvance | Pneumococcal 15 | 4.50 mg sodium chloride |
| Yeast | Medium Nutrient | Vaxneuvance | Pneumococcal 15 | Amount not specified in package insert |
| Albumin, Bovine | Stabilizer | Zostavax | Varicella Zoster | Trace amounts |
| DNA | Residual Medium | Zostavax | Varicella Zoster | Residual |
| Gelatin, Porcine, Hydrolyzed | Stabilizer | Zostavax | Varicella Zoster | 15.58 mg/0.65 mL dose |
| Monosodium L-glutamate | Stabilizer | Zostavax | Varicella Zoster | 0.62 mg/0.65 mL dose |
| MRC-5 | Manufacturing Residue | Zostavax | Varicella Zoster | Residual |
| Neomycin | Antimicrobial | Zostavax | Varicella Zoster | Trace amounts |
| Phosphate Buffer | Buffer | Zostavax | Varicella Zoster | 0.10 mg/0.65 mL dose potassium phosphate monobasic 0.57 mg/0.65 mL dose sodium phosphate monobasic |
| Potassium Chloride | Buffer | Zostavax | Varicella Zoster | 0.10 mg/0.65 mL dose |
| Salts, Mineral | Adjust tonicity | Zostavax | Varicella Zoster | 3.99 mg/0.65 mL dose sodium chloride |
| Sucrose | Stabilizer | Zostavax | Varicella Zoster | 31.16 mg/0.65 mL dose |
| This information is correct to the best of our knowledge. Please report inaccuracies to us at info@hopkinsvaccine.org This table was last updated on October 14, 2024 | © 2024 Institute for Vaccine Safety |
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