Excipients in Vaccines Not Routinely Recommended in the US

updated October 2024

The information in this table is for Excipients in Vaccines Not Routinely Recommended in the US

Click Column title to sort

ExcipientPurposeVaccine NameVaccine TypeAmount per 0.5 mL Dose (unless otherwise noted)
2-PhenoxyethanolPreservativeIPOLPolio0.5%
AcetoneSolventAdenovirus Type 4 and Type 7Adenovirus Type 4 and Type 7Amount not specified in PI
Albumin, Bovine Calf Serum ProteinStabilizerIPOLPolio<50 ng
Albumin, Bovine SerumStabilizerIxiaroJapanese Encephalitis≤100 ng/mL
Albumin, Egg (Ovalbumin)Residual MediumRabAvertRabies≤3 ng/1 mL dose
Albumin, HumanDiluent/StabilizerACAM2000Smallpox/Mpox2%
Albumin, HumanDiluent/StabilizerAdenovirus Type 4 and Type 7Adenovirus Type 4 and Type 7Amount not specified in PI
Albumin, HumanStabilizerImovaxRabies<100 mg/mL
Albumin, HumanDiluent/StabilizerRabAvertRabies≤0.3 mg/1 mL dose
Albumin, HumanDiluent/StabilizerTICOVACTick-borne Encephalitis0.5 mg
Albumin, Human (recombinant, rice-derived)StabilizerERVEBOEbola, Zaire2.5 mg/1 mL dose
Albumin, Human (WI-38)Diluent/StabilizerAdenovirus Type 4 and Type 7Adenovirus Type 4 and Type 7Amount not specified in PI
AlcoholSolventAdenovirus Type 4 and Type 7Adenovirus Type 4 and Type 7Amount not specified in PI
AluminumAdjuvantCyrendusAnthrax1.3 mg/mL
Aluminum HydroxideAdjuvantBioThraxAnthrax1.2 mg/mL aluminum
Aluminum HydroxideAdjuvantIxiaroJapanese Encephalitis250 mcg
Aluminum HydroxideAdjuvantTICOVACTick-borne Encephalitis0.35 mg
Amino AcidMedium NutrientVivotifTyphoid0.3-3.0 mg
Amino AcidsMediumBioThraxAnthraxAmount not specified in PI
Amino AcidsStabilizerCyrendusAnthraxAmount not specified in PI
Amino Acids, EssentialStabilizerDENGVAXIADengue0.56 mg including l-phenylalanine
Amino Acids, Non-essentialStabilizerDENGVAXIADengue0.2 mg
Amphotericin BAntimicrobialRabAvertRabies≤20 ng/1 mL dose
Anhydrous lactoseBulking AgentVAXCHORACholera≤2.09 gc
Anhydrous lactoseManufacturing Flow AidVAXCHORACholera0.18–0.22 g
Ascorbic acidStabilizerVAXCHORACholera≤8.55 mg
Ascorbic acidBuffer and NeutralizerVAXCHORACholera1.50–1.80 g
Ascorbic AcidAntioxidantVivotifTyphoid0.2-2.4 mg/capsule
AsparagineMedium NutrientBCG VaccineBCGAmount not specified in PI
Benzethonium ChloridePreservativeBioThraxAnthrax25 mcg/mL
Benzethonium ChloridePreservativeCyrendusAnthrax25 mcg/mL
BenzonaseProtein PurifierERVEBOEbola, Zaire≤15 ng/1 mL dose
BenzonaseProtein PurifierJynneosSmallpox/Mpox≤ 0.0025 mcg
Beta-propiolactoneViral InactivatorAUDENZInfluenza H5N1≤0.1 mcg
Beta-PropiolactoneViral InactivatorImovaxRabies<50 ppm
Beta-PropiolactoneViral InactivatorRabAvertRabiesAmount not specified in PI
Bovine CaseinMedium NutrientTyphim ViTyphoidAmount not specified in PI
Bovine CaseinMedium NutrientVivotifTyphoidAmount not specified in PI
Bovine SerumStabilizerRabAvertRabies“Small quantities’, US origin
Calf lymph vaccineGrowth MediumACAM2000Smallpox/MpoxAmount not specified in PI
Castor OilTablet CoatingAdenovirus Type 4 and Type 7Adenovirus Type 4 and Type 7Amount not specified in PI
Cell-free FiltrateMedium/VaccineCyrendusAnthrax100 mcg/mL
Cellulose, Acetate PhthalateControls formulation releaseAdenovirus Type 4 and Type 7Adenovirus Type 4 and Type 7Amount not specified in PI
Cellulose, MicrocrystallineStabilizerAdenovirus Type 4 and Type 7Adenovirus Type 4 and Type 7Amount not specified in PI
Cetyltrimethylammonium Bromide (CTAB)Protein PurifierAUDENZInfluenza H5N1≤ 4.5 mcg
Chick EmbryoResidual MediumRabAvertRabiesNo intact cells (may have trace residual protein)
Chick Embryo Fibroblast cellsResidual MediumJynneosSmallpox/MpoxAmount not specified in PI
Chick FibroblastsGrowth MediumRabAvertRabiesminimal amounts protein residual
Chick ProteinResidual MediumTICOVACTick-borne EncephalitisTrace Amounts
Chicken EmbryoResidual MediumYF-VAXYellow FeverAmount not specified in PI
ChlortetracyclineAntimicrobialRabAvertRabies≤200 ng/1 mL dose
CiprofloxacinAntimicrobialJynneosSmallpox/Mpox≤ 0.005 mcg
Citric AcidMedium NutrientBCG VaccineBCGAmount not specified in PI
Citric Acid MonohydrateMedium NutrientAUDENZInfluenza H5N10.04 mg at pH 6.5-7.7
CPG 7909AdjuvantCyrendusAnthrax0.5 mg/mL
DextroseMedium NutrientAdenovirus Type 4 and Type 7Adenovirus Type 4 and Type 7Amount not specified in PI
DextroseMedium NutrientVivotifTyphoidAmount not specified in PI
D-fructoseMedium NutrientAdenovirus Type 4 and Type 7Adenovirus Type 4 and Type 7Amount not specified in PI
Dibasic Sodium PhosphateBufferTICOVACTick-borne Encephalitis0.22 mg
D-mannoseStabilizerAdenovirus Type 4 and Type 7Adenovirus Type 4 and Type 7Amount not specified in PI
DMEMGrowth MediumAdenovirus Type 4 and Type 7Adenovirus Type 4 and Type 7Amount not specified in PI
DNAResidual MediumIxiaroJapanese Encephalitis≤200 pg/mL (host cell DNA)
DNAResidual MediumJynneosSmallpox/Mpox≤20 mcg Host Cell DNA
DNA from CEF cellsResidual MediumTICOVACTick-borne EncephalitisTrace amounts
D-sorbitolStabilizerDENGVAXIADengue9.38 mg
D-trehalose DihydrateStabilizerDENGVAXIADengue13.75 mg
EDTAPreservativeRabAvertRabies0.3 mg/1 mL dose sodium EDTA
Fetal Bovine SerumGrowth MediumAdenovirus Type 4 and Type 7Adenovirus Type 4 and Type 7Amount not specified in PI
FormaldehydePreservativeBioThraxAnthrax100 mcg/mL
FormaldehydePreservativeCyrendusAnthrax100 mcg/mL
FormaldehydeInactivating AgentInfluenza H5N1 sanofiInfluenza H5N1≤200 mcg/1 mL dose
FormaldehydeInactivating AgentIPOLPolio≤0.02%
FormaldehydeInactivating AgentIxiaroJapanese Encephalitis≤200 pmm
FormaldehydeInactivating AgentTICOVACTick-borne Encephalitis≤5 mcg
FormaldehydeInactivating AgentTyphim ViTyphoid≤100 mcg (residual)
GalactoseMedium NutrientVivotifTyphoidAmount not specified in PI
GelatinGelatin CapsulesVivotifTyphoidGelatin Capsule
GelatinStabilizerYF-VAXYellow FeverAmount not specified in PI
Gelatin, BovineStabilizer, solventRabAvertRabies≤12 mg/1 mL dose polygeline
Gelatin, PorcineStabilizerInfluenza H5N1 sanofiInfluenza H5N1500 mcg
GentamicinAntimicrobialJynneosSmallpox/Mpox≤ 0.400 mcg
GentamicinAntimicrobialTICOVACTick-borne EncephalitisTrace amounts
GlycerinMedium NutrientACAM2000Smallpox/Mpox50% (v/v)
GlycerinMedium NutrientBCG VaccineBCGAmount not specified in PI
Hexadecyltrimethylammonium BromideProtein PurifierTyphim ViTyphoidAmount not specified in PI
Host Cell DNAResidual MediumERVEBOEbola, Zaire≤10 ng/1 mL dose
Hy-Case SF (hydrolyzed casein)StabilizerVAXCHORACholera≤ 17.11 mg
Iron Ammonium CitrateMedium NutrientBCG VaccineBCGAmount not specified in PI
LactoseFreezing stabilizerBCG VaccineBCGAmount not specified in PI
LactoseStabilizerVivotifTyphoid<180-200 mg/capsule
Lactose, AnhydrousStabilizerAdenovirus Type 4 and Type 7Adenovirus Type 4 and Type 7Amount not specified in PI
L-arginine HydrochlorideStabilizerDENGVAXIADengue2.5 mg
M-199 MediumMediumIPOLPolioAmount not specified in PI
Madin Darby Canine Kidney (MDCK) cell DNAResidual MediumAUDENZInfluenza H5N1≤10 ng
Madin Darby Canine Kidney (MDCK) cell proteinResidual MediumAUDENZInfluenza H5N1≤3.15 mcg
Magnesium StearateLubricant for capsule fillingAdenovirus Type 4 and Type 7Adenovirus Type 4 and Type 7Amount not specified in PI
Magnesium StearateLubricant for capsule fillingVivotifTyphoid3.6-4.0 mg/capsule
Magnesium SulfateMedium NutrientBCG VaccineBCGAmount not specified in PI
MannitolStabilizerACAM2000Smallpox/Mpox5%
MF59C.1 Adjuvant (MF59)AdjuvantAUDENZInfluenza H5N1Amount not specified in PH
Monobasic Potassium PhosphateBufferTICOVACTick-borne Encephalitis0.045 mg
Monosodium GlutamateStabilizerAdenovirus Type 4 and Type 7Adenovirus Type 4 and Type 7Amount not specified in PI
MRC-5 cellsManufacturing ResidueImovaxRabiesAmount not specified in PI
NeomycinAntimicrobialACAM2000Smallpox/MpoxTrace Amounts
NeomycinAntimicrobialIPOLPolio<5 ng
NeomycinAntimicrobialRabAvertRabies<10 mcg/1 mL dose
NeomycinAntimicrobialTICOVACTick-borne EncephalitisTrace amounts
Neomycin SulfateAntimicrobialImovaxRabies<150 mcg/mL
PhenolPreservativeACAM2000Smallpox/Mpox0.25% (v/v)
PhenolPreservativeTyphim ViTyphoid0.25%
Phenol Red IndicatorpH indicator, dyeImovaxRabies20 mcg/mL
Phosphate BufferBufferIxiaroJapanese EncephalitisSodium chloride
Potassium dihydrogen phosphate
Disodium hydrogen phosphate
Phosphate BufferBufferTyphim ViTyphoid0.065 mg disodium phosphate
0.023 mg monosodium phosphate
Plasdone CImproves solubilityAdenovirus Type 4 and Type 7Adenovirus Type 4 and Type 7Amount not specified in PI
Polacrilin PotassiumBufferAdenovirus Type 4 and Type 7Adenovirus Type 4 and Type 7Amount not specified in PI
PolydimethylsiloxaneAntifoamTyphim ViTyphoidResidual, fatty-acid ester-based antifoam
Polyethylene Glycol p-Isoctylpheny Ether (Triton X-100)SurfactantInfluenza H5N1 sanofiInfluenza H5N1<0.05%/1 mL dose
Polymyxin BAntimicrobialACAM2000Smallpox/MpoxTrace Amounts
Polymyxin BAntimicrobialIPOLPolio25 ng
Polysorbate 80SurfactantAUDENZInfluenza H5N11.175 mg
Potassium GlutamateStabilizerRabAvertRabies1 mg/1 mL dose
Potassium PhosphateBufferAdenovirus Type 4 and Type 7Adenovirus Type 4 and Type 7Amount not specified in PI
Potassium PhosphateMedium nutrientBCG VaccineBCGAmount not specified in PI
Protamine SulfateProtein PurifierIxiaroJapanese Encephalitis≤1 mcg/mL
Protamine SulfateProtein PurifierTICOVACTick-borne Encephalitis≤0.5 mcg
ProteinResidual MediumIxiaroJapanese Encephalitis≤100 ng/mL host cell protein
ProteinResidual MediumJynneosSmallpox/Mpox≤500 mcg
Rice ProteinResidual MediumERVEBOEbola, ZaireTrace amounts
Salt, inorganicMediumBioThraxAnthraxAmount not specified in PI
Salt, InorganicMediumCyrendusAnthraxAmount not specified in PI
Salts, MineralAdjust tonicityYF-VaxYellow FeverIngredient in Diluent
Sodium BicarbonateBufferAdenovirus Type 4 and Type 7Adenovirus Type 4 and Type 7Amount not specified in PI
Sodium BicarbonateBufferVAXCHORACholera2.16–2.41 g
Sodium CarbonateBufferVAXCHORACholera0.24-0.49 g
Sodium ChlorideBufferACAM2000Smallpox/Mpox0.5- 0.7%
Sodium ChlorideBufferBioThraxAnthrax0.85%
Sodium ChlorideBufferCyrendusAnthrax0.85%
Sodium ChlorideBuffer/DiluentDENGVAXIADengue2mg
Sodium ChlorideAdjust tonicityJynneosSmallpox/Mpox140 mM at pH 7.7
Sodium ChlorideBufferTICOVACTick-borne Encephalitis3.45 mg
Sodium ChlorideAdjust tonicityTyphim ViTyphoid4.150 mg
Sodium Citrate DihydrateBufferAUDENZInfluenza H5N10.66 mg
Sodium MetabisulphiteStabilizerIxiaroJapanese Encephalitis≤200 ppm
Sorbitan TrioleateStabilizerAUDENZInfluenza H5N11.175 mg
SorbitolStabilizerYF-VAXYellow FeverAmount not specified in PI
SqualeneAdjuvantAUDENZInfluenza H5N19.75 mg
StreptomycinAntimicrobialIPOLPolio200 ng
SucroseStabilizerAdenovirus Type 4 and Type 7Adenovirus Type 4 and Type 7Amount not specified in PI
SucroseStabilizerDENGVAXIADengue18.75 mg
SucroseStabilizerInfluenza H5N1 sanofiInfluenza H5N1≤2.0%/1 mL dose
SucroseStabilizerTICOVACTick-borne Encephalitis≤15 mg
SucroseStabilizerVAXCHORACholera≤165.37 mg
SucroseStabilizerVivotifTyphoid3.3-34.2 mg/capsule
SugarsMediumBioThraxAnthraxAmount not specified in PI
SugarsMediumCyrendusAnthraxAmount not specified in PI
ThimerosalPreservativeAUDENZInfluenza H5N125 mcg mercury in 0.5mL dose
ThimerosalPreservativeInfluenza H5N1 sanofiInfluenza H5N198.2 mcg/1 mL dose (50 mcg mercury)
TrometamolStabilizerDENGVAXIADengue0.18 mg
TromethamineStabilizerJynneosSmallpox/Mpox10 mM
Tromethamine (Tris)StabilizerERVEBOEbola, Zaire10 mM/1 mL dose
UreaStabilizerDENGVAXIADengue0.63 mg
Vero CellsGrowth MediumACAM2000Smallpox/MpoxAmount not specified in PI
Vero CellsGrowth MediumDENGVAXIADengueAmount not specified in PI
Vero CellsGrowth MediumIPOLPolioAmount not specified in PI
Vero cellsMedium NutrientIxiaroJapanese EncephalitisAmount not specified in PI
VitaminsMediumBioThraxAnthraxAmount not specified in PI
VitaminsMediumCyrendusAnthraxAmount not specified in PI
YeastMedium NutrientVivotifTyphoidAmount not specified in PI
Yellow #6 Aluminum Lake DyeColorantAdenovirus Type 4 and Type 7Adenovirus Type 4 and Type 7Amount not specified in PI

 

This information is correct to the best of our knowledge. Please report inaccuracies to us at info@hopkinsvaccine.org
This table was last updated on October 14, 2024 | © 2024 Institute for Vaccine Safety