Excipients in Vaccines Not Routinely Recommended in the US
updated December 2024
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Excipient Purpose Vaccine Name Vaccine Type Amount per 0.5 mL dose* Albumin, Human Diluent/Stabilizer ACAM2000 Smallpox/Mpox 2% Calf lymph vaccine Growth Medium ACAM2000 Smallpox/Mpox Amount not specified in PI Glycerin Medium Nutrient ACAM2000 Smallpox/Mpox 50% (v/v) Mannitol Stabilizer ACAM2000 Smallpox/Mpox 5% Neomycin Antimicrobial ACAM2000 Smallpox/Mpox Trace Amounts Phenol Preservative ACAM2000 Smallpox/Mpox 0.25% (v/v) Polymyxin B Antimicrobial ACAM2000 Smallpox/Mpox Trace Amounts Sodium Chloride Buffer ACAM2000 Smallpox/Mpox 0.5- 0.7% Vero Cells Growth Medium ACAM2000 Smallpox/Mpox Amount not specified in PI Acetone Solvent Adenovirus Type 4 and Type 7 Adenovirus Type 4 and Type 7 Amount not specified in PI Albumin, Human Diluent/Stabilizer Adenovirus Type 4 and Type 7 Adenovirus Type 4 and Type 7 Amount not specified in PI Albumin, Human (WI-38) Diluent/Stabilizer Adenovirus Type 4 and Type 7 Adenovirus Type 4 and Type 7 Amount not specified in PI Alcohol Solvent Adenovirus Type 4 and Type 7 Adenovirus Type 4 and Type 7 Amount not specified in PI Castor Oil Tablet Coating Adenovirus Type 4 and Type 7 Adenovirus Type 4 and Type 7 Amount not specified in PI Cellulose, Acetate Phthalate Controls formulation release Adenovirus Type 4 and Type 7 Adenovirus Type 4 and Type 7 Amount not specified in PI Cellulose, Microcrystalline Stabilizer Adenovirus Type 4 and Type 7 Adenovirus Type 4 and Type 7 Amount not specified in PI Dextrose Medium Nutrient Adenovirus Type 4 and Type 7 Adenovirus Type 4 and Type 7 Amount not specified in PI D-fructose Medium Nutrient Adenovirus Type 4 and Type 7 Adenovirus Type 4 and Type 7 Amount not specified in PI D-mannose Stabilizer Adenovirus Type 4 and Type 7 Adenovirus Type 4 and Type 7 Amount not specified in PI DMEM Growth Medium Adenovirus Type 4 and Type 7 Adenovirus Type 4 and Type 7 Amount not specified in PI Fetal Bovine Serum Growth Medium Adenovirus Type 4 and Type 7 Adenovirus Type 4 and Type 7 Amount not specified in PI Lactose, Anhydrous Stabilizer Adenovirus Type 4 and Type 7 Adenovirus Type 4 and Type 7 Amount not specified in PI Magnesium Stearate Lubricant for capsule filling Adenovirus Type 4 and Type 7 Adenovirus Type 4 and Type 7 Amount not specified in PI Monosodium Glutamate Stabilizer Adenovirus Type 4 and Type 7 Adenovirus Type 4 and Type 7 Amount not specified in PI Plasdone C Improves solubility Adenovirus Type 4 and Type 7 Adenovirus Type 4 and Type 7 Amount not specified in PI Polacrilin Potassium Buffer Adenovirus Type 4 and Type 7 Adenovirus Type 4 and Type 7 Amount not specified in PI Potassium Phosphate Buffer Adenovirus Type 4 and Type 7 Adenovirus Type 4 and Type 7 Amount not specified in PI Sodium Bicarbonate Buffer Adenovirus Type 4 and Type 7 Adenovirus Type 4 and Type 7 Amount not specified in PI Sucrose Stabilizer Adenovirus Type 4 and Type 7 Adenovirus Type 4 and Type 7 Amount not specified in PI Yellow #6 Aluminum Lake Dye Colorant Adenovirus Type 4 and Type 7 Adenovirus Type 4 and Type 7 Amount not specified in PI Beta-propiolactone Viral Inactivator AUDENZ Influenza H5N1 ≤0.1 mcg Cetyltrimethylammonium Bromide (CTAB) Protein Purifier AUDENZ Influenza H5N1 ≤ 4.5 mcg Citric Acid Monohydrate Medium Nutrient AUDENZ Influenza H5N1 0.04 mg at pH 6.5-7.7 Madin Darby Canine Kidney (MDCK) cell DNA Residual Medium AUDENZ Influenza H5N1 ≤10 ng Madin Darby Canine Kidney (MDCK) cell protein Residual Medium AUDENZ Influenza H5N1 ≤3.15 mcg MF59C.1 Adjuvant (MF59) Adjuvant AUDENZ Influenza H5N1 Amount not specified in PH Polysorbate 80 Surfactant AUDENZ Influenza H5N1 1.175 mg Sodium Citrate Dihydrate Buffer AUDENZ Influenza H5N1 0.66 mg Sorbitan Trioleate Stabilizer AUDENZ Influenza H5N1 1.175 mg Squalene Adjuvant AUDENZ Influenza H5N1 9.75 mg Thimerosal Preservative AUDENZ Influenza H5N1 25 mcg mercury in 0.5mL dose Asparagine Medium Nutrient BCG Vaccine BCG Amount not specified in PI Citric Acid Medium Nutrient BCG Vaccine BCG Amount not specified in PI Glycerin Medium Nutrient BCG Vaccine BCG Amount not specified in PI Iron Ammonium Citrate Medium Nutrient BCG Vaccine BCG Amount not specified in PI Lactose Freezing stabilizer BCG Vaccine BCG Amount not specified in PI Magnesium Sulfate Medium Nutrient BCG Vaccine BCG Amount not specified in PI Potassium Phosphate Medium nutrient BCG Vaccine BCG Amount not specified in PI Aluminum Hydroxide Adjuvant BioThrax Anthrax 1.2 mg/mL aluminum Amino Acids Medium BioThrax Anthrax Amount not specified in PI Benzethonium Chloride Preservative BioThrax Anthrax 25 mcg/mL Formaldehyde Preservative BioThrax Anthrax 100 mcg/mL Salt, inorganic Medium BioThrax Anthrax Amount not specified in PI Sodium Chloride Buffer BioThrax Anthrax 0.85% Sugars Medium BioThrax Anthrax Amount not specified in PI Vitamins Medium BioThrax Anthrax Amount not specified in PI Aluminum Adjuvant Cyrendus Anthrax 1.3 mg/mL Amino Acids Stabilizer Cyrendus Anthrax Amount not specified in PI Benzethonium Chloride Preservative Cyrendus Anthrax 25 mcg/mL Cell-free Filtrate Medium/Vaccine Cyrendus Anthrax 100 mcg/mL CPG 7909 Adjuvant Cyrendus Anthrax 0.5 mg/mL Formaldehyde Preservative Cyrendus Anthrax 100 mcg/mL Salt, Inorganic Medium Cyrendus Anthrax Amount not specified in PI Sodium Chloride Buffer Cyrendus Anthrax 0.85% Sugars Medium Cyrendus Anthrax Amount not specified in PI Vitamins Medium Cyrendus Anthrax Amount not specified in PI Amino Acids, Essential Stabilizer DENGVAXIA Dengue 0.56 mg including l-phenylalanine Amino Acids, Non-essential Stabilizer DENGVAXIA Dengue 0.2 mg D-sorbitol Stabilizer DENGVAXIA Dengue 9.38 mg D-trehalose Dihydrate Stabilizer DENGVAXIA Dengue 13.75 mg L-arginine Hydrochloride Stabilizer DENGVAXIA Dengue 2.5 mg Sodium Chloride Buffer/Diluent DENGVAXIA Dengue 2mg Sucrose Stabilizer DENGVAXIA Dengue 18.75 mg Trometamol Stabilizer DENGVAXIA Dengue 0.18 mg Urea Stabilizer DENGVAXIA Dengue 0.63 mg Vero Cells Growth Medium DENGVAXIA Dengue Amount not specified in PI Albumin, Human (recombinant, rice-derived) Stabilizer ERVEBO Ebola, Zaire 2.5 mg/1 mL dose Benzonase Protein Purifier ERVEBO Ebola, Zaire ≤15 ng/1 mL dose Host Cell DNA Residual Medium ERVEBO Ebola, Zaire ≤10 ng/1 mL dose Rice Protein Residual Medium ERVEBO Ebola, Zaire Trace amounts Tromethamine (Tris) Stabilizer ERVEBO Ebola, Zaire 10 mM/1 mL dose Albumin, Human Stabilizer Imovax Rabies <100 mg/mL Beta-Propiolactone Viral Inactivator Imovax Rabies <50 ppm MRC-5 cells Manufacturing Residue Imovax Rabies Amount not specified in PI Neomycin Sulfate Antimicrobial Imovax Rabies <150 mcg/mL Phenol Red Indicator pH indicator, dye Imovax Rabies 20 mcg/mL Formaldehyde Inactivating Agent Influenza H5N1 sanofi Influenza H5N1 ≤200 mcg/1 mL dose Gelatin, Porcine Stabilizer Influenza H5N1 sanofi Influenza H5N1 500 mcg Polyethylene Glycol p-Isoctylpheny Ether (Triton X-100) Surfactant Influenza H5N1 sanofi Influenza H5N1 <0.05%/1 mL dose Sucrose Stabilizer Influenza H5N1 sanofi Influenza H5N1 ≤2.0%/1 mL dose Thimerosal Preservative Influenza H5N1 sanofi Influenza H5N1 98.2 mcg/1 mL dose (50 mcg mercury) 2-Phenoxyethanol Preservative IPOL Polio 0.5% Albumin, Bovine Calf Serum Protein Stabilizer IPOL Polio <50 ng Formaldehyde Inactivating Agent IPOL Polio ≤0.02% M-199 Medium Medium IPOL Polio Amount not specified in PI Neomycin Antimicrobial IPOL Polio <5 ng Polymyxin B Antimicrobial IPOL Polio 25 ng Streptomycin Antimicrobial IPOL Polio 200 ng Vero Cells Growth Medium IPOL Polio Amount not specified in PI Albumin, Fetal Bovine Serum Stabilizer IXCHIQ Chikungunya <500 pg Albumin, Recombinant Human Stabilizer IXCHIQ Chikungunya 0.05 mg Amino Acids Stabilizer IXCHIQ Chikungunya Amount not specified in PI Phosphate Buffer Buffer IXCHIQ Chikungunya 0.313 mg Di-potassium Hydrogen Phosphate
0.098 mg Potassium di-hydrogen PhosphateD-sorbitol Stabilizer IXCHIQ Chikungunya 2.5 mg L-methionine Amino acid, nutrient IXCHIQ Chikungunya 0.75 mg Magnesium Chloride Hexahydrate Salt, buffer IXCHIQ Chikungunya 0.51 mg Protamine Sulfate Protein Purifier IXCHIQ Chikungunya < 1 mcg Sucrose Stabilizer IXCHIQ Chikungunya 25 mg Trisodium Citrate Di-hydrate Buffer IXCHIQ Chikungunya 3.68 mg Vero cell DNA Residual Medium IXCHIQ Chikungunya <10 pg Vero cells protein Residual medium IXCHIQ Chikungunya <5 ng Vitamins Medium IXCHIQ Chikungunya Amount not specified in PI Albumin, Bovine Serum Stabilizer Ixiaro Japanese Encephalitis ≤100 ng/mL Aluminum Hydroxide Adjuvant Ixiaro Japanese Encephalitis 250 mcg DNA Residual Medium Ixiaro Japanese Encephalitis ≤200 pg/mL (host cell DNA) Formaldehyde Inactivating Agent Ixiaro Japanese Encephalitis ≤200 pmm Phosphate Buffer Buffer Ixiaro Japanese Encephalitis Sodium chloride
Potassium dihydrogen phosphate
Disodium hydrogen phosphateProtamine Sulfate Protein Purifier Ixiaro ≤1 mcg/mL Protein Residual Medium Ixiaro Japanese Encephalitis ≤100 ng/mL host cell protein Sodium Metabisulphite Stabilizer Ixiaro Japanese Encephalitis ≤200 ppm Vero cells Medium Nutrient Ixiaro Japanese Encephalitis Amount not specified in PI Benzonase Protein Purifier Jynneos Smallpox/Mpox ≤ 0.0025 mcg Chick Embryo Fibroblast cells Residual Medium Jynneos Smallpox/Mpox Amount not specified in PI Ciprofloxacin Antimicrobial Jynneos Smallpox/Mpox ≤ 0.005 mcg DNA Residual Medium Jynneos Smallpox/Mpox ≤20 mcg Host Cell DNA Gentamicin Antimicrobial Jynneos Smallpox/Mpox ≤ 0.400 mcg Protein Residual Medium Jynneos Smallpox/Mpox ≤500 mcg Sodium Chloride Adjust tonicity Jynneos Smallpox/Mpox 140 mM at pH 7.7 Tromethamine Stabilizer Jynneos Smallpox/Mpox 10 mM Albumin, Egg (Ovalbumin) Residual Medium RabAvert Rabies ≤3 ng/1 mL dose Albumin, Human Diluent/Stabilizer RabAvert Rabies ≤0.3 mg/1 mL dose Amphotericin B Antimicrobial RabAvert Rabies ≤20 ng/1 mL dose Beta-Propiolactone Viral Inactivator RabAvert Rabies Amount not specified in PI Bovine Serum Stabilizer RabAvert Rabies “Small quantities’, US origin Chick Embryo Residual Medium RabAvert Rabies No intact cells (may have trace residual protein) Chick Fibroblasts Growth Medium RabAvert Rabies minimal amounts protein residual Chlortetracycline Antimicrobial RabAvert Rabies ≤200 ng/1 mL dose EDTA Preservative RabAvert Rabies 0.3 mg/1 mL dose sodium EDTA Gelatin, Bovine Stabilizer, solvent RabAvert Rabies ≤12 mg/1 mL dose polygeline Neomycin Antimicrobial RabAvert Rabies <10 mcg/1 mL dose Potassium Glutamate Stabilizer RabAvert Rabies 1 mg/1 mL dose Albumin, Human Diluent/Stabilizer TICOVAC Tick-borne Encephalitis 0.5 mg Aluminum Hydroxide Adjuvant TICOVAC Tick-borne Encephalitis 0.35 mg Chick Protein Residual Medium TICOVAC Tick-borne Encephalitis Trace Amounts Dibasic Sodium Phosphate Buffer TICOVAC Tick-borne Encephalitis 0.22 mg DNA from CEF cells Residual Medium TICOVAC Tick-borne Encephalitis Trace amounts Formaldehyde Inactivating Agent TICOVAC Tick-borne Encephalitis ≤5 mcg Gentamicin Antimicrobial TICOVAC Tick-borne Encephalitis Trace amounts Monobasic Potassium Phosphate Buffer TICOVAC Tick-borne Encephalitis 0.045 mg Neomycin Antimicrobial TICOVAC Tick-borne Encephalitis Trace amounts Protamine Sulfate Protein Purifier TICOVAC Tick-borne Encephalitis ≤0.5 mcg Sodium Chloride Buffer TICOVAC Tick-borne Encephalitis 3.45 mg Sucrose Stabilizer TICOVAC Tick-borne Encephalitis ≤15 mg Bovine Casein Medium Nutrient Typhim Vi Typhoid Amount not specified in PI Formaldehyde Inactivating Agent Typhim Vi Typhoid ≤100 mcg (residual) Hexadecyltrimethylammonium Bromide Protein Purifier Typhim Vi Typhoid Amount not specified in PI Phenol Preservative Typhim Vi Typhoid 0.25% Phosphate Buffer Buffer Typhim Vi Typhoid 0.065 mg disodium phosphate
0.023 mg monosodium phosphatePolydimethylsiloxane Antifoam Typhim Vi Typhoid Residual, fatty-acid ester-based antifoam Sodium Chloride Adjust tonicity Typhim Vi Typhoid 4.150 mg Anhydrous lactose Bulking Agent VAXCHORA Cholera ≤2.09 gc Anhydrous lactose Manufacturing Flow Aid VAXCHORA Cholera 0.18–0.22 g Ascorbic acid Stabilizer VAXCHORA Cholera ≤8.55 mg Ascorbic acid Buffer and Neutralizer VAXCHORA Cholera 1.50–1.80 g Hy-Case SF (hydrolyzed casein) Stabilizer VAXCHORA Cholera ≤ 17.11 mg Sodium Bicarbonate Buffer VAXCHORA Cholera 2.16–2.41 g Sodium Carbonate Buffer VAXCHORA Cholera 0.24-0.49 g Sucrose Stabilizer VAXCHORA Cholera ≤165.37 mg Amino Acid Medium Nutrient Vivotif Typhoid 0.3-3.0 mg Ascorbic Acid Antioxidant Vivotif Typhoid 0.2-2.4 mg/capsule Bovine Casein Medium Nutrient Vivotif Typhoid Amount not specified in PI Dextrose Medium Nutrient Vivotif Typhoid Amount not specified in PI Galactose Medium Nutrient Vivotif Typhoid Amount not specified in PI Gelatin Gelatin Capsules Vivotif Typhoid Gelatin Capsule Lactose Stabilizer Vivotif Typhoid <180-200 mg/capsule Magnesium Stearate Lubricant for capsule filling Vivotif Typhoid 3.6-4.0 mg/capsule Sucrose Stabilizer Vivotif Typhoid 3.3-34.2 mg/capsule Yeast Medium Nutrient Vivotif Typhoid Amount not specified in PI Chicken Embryo Residual Medium YF-VAX Yellow Fever Amount not specified in PI Gelatin Stabilizer YF-VAX Yellow Fever Amount not specified in PI Salts, Mineral Adjust tonicity YF-Vax Yellow Fever Ingredient in Diluent Sorbitol Stabilizer YF-VAX Yellow Fever Amount not specified in PI This information is correct to the best of our knowledge. Please report inaccuracies to us at info@hopkinsvaccine.org
This table was last updated on December 20, 2024 | © 2024 Institute for Vaccine Safety -
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