Vaccines can cause deltoid bursitis when administered incorrectly.
The 2012 report by the Institute of Medicine (IOM), now called the National Academy of Medicine (NAM), described one study assessing an association between the injection of a vaccine and deltoid bursitis ; however, this study did not provide convincing evidence due to a lack of validity and precision . No relevant studies of quality have been published since this report.
A vaccine that is unintentionally injected into the synovial tissue structures underlying the deltoid muscle can induce a prolonged immune-mediated inflammatory response [3-5]. Such an error in vaccine administration could occur due to inappropriate needle length or improper injection technique involving administration in the upper one-third of the muscle [6-10]. The 2012 IOM report described several cases providing strong clinical evidence that vaccine injection was a contributing cause of the rapid development of deltoid bursitis [11, 12]
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