COVID-19 Vaccine Details - Institute for Vaccine Safety

Manufacturer	Moderna	Pfizer-BioNTech	Janssen
Type	mRNA	mRNA	Adenovirus type 26 (Ad26)-vectored
Indicated Ages	18 years and older	12 years and older	18 years and older
Dose	0.5 mL	0.3 mL	0.5 mL
Schedule	2 doses; 1 month apart	2 doses; 3 weeks apart	1 dose
Route	Intramuscular	Intramuscular	Intramuscular
Appearance	White to off-white suspension may contain white or translucent product-related particulates	White to off-white suspension and may contain white to off-white opaque amorphous particles.	Colorless to slightly yellow, clear to very opalescent.
Concentration	100 mcg of nucleosidemodified messenger RNA (mRNA) encoding the pre-fusion stabilized Spike glycoprotein (S) of SARS-CoV-2 virus	30 mcg of a nucleoside-modified messenger RNA (modRNA) encoding the viral spike (S) glycoprotein of SARS-CoV-2	5×10¹⁰ viral particles
Preservative	None	None	None
Adjuvant	None	None	None
Excipients	Lipids: (SM-102, polyethylene glycol [PEG] 2000 dimyristoyl glycerol [DMG], 1.93 mg Cholesterol 1,2-distearoyl-sn-glycero-3-phosphocholine [DSPC]) Tromethamine, 0.31 mg Tromethamine hydrochloride, 1.18 mg Acetic acid, 0.043 mg Sodium acetate, 0.12 mg Sucrose, 43.5 mg	Lipids: (4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate), 0.43 mg 2[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide, 0.05 mg 1,2-distearoyl-sn-glycero-3-phosphocholine, 0.09 mg Cholesterol, 0.2 mg Potassium chloride, 0.01 mg Phosphate Buffer: Dibasic sodium phosphate dihydrate, 0.07 mg Sodium chloride, 0.36 mg Monobasic potassium phosphate, 0.01 mg Sucrose, 6 mg	Citric acid monohydrate Trisodium citrate dihydrate Ethanol 2-hydroxypropyl-β-cyclodextrin (HBCD) Polysorbate 80 Sodium chloride Sodium hydroxide Hydrochloric acid Amino Acids (from media)
Allergens	(SM-102, polyethylene glycol [PEG] 2000 dimyristoyl glycerol [DMG], 1.93 mg	2[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide, 0.05 mg	Polysorbate 80
Media	None	None	PER.C6® TetR Cell Line (no animal components)
Diluent	None	(0.9% Sodium Chloride Injection, USP) contributes an additional 2.16 mg sodium chloride per dose	None
Packaging	Multiple-dose Vials are supplied as a carton of 10 multiple-dose vials	Multipl-dose Vials (after dilution each vial contains 5 doses of 0.3 mL)	Multiple-dose Vials containing 5 doses (5 mL each)
Storage	• Stored frozen between -25°C to -15°C (-13°F to 5°F). • Do not store on dry ice or below -40ºC (-40ºF). • Vials can be stored refrigerated between 2° to 8°C (36° to 46°F) for up to 30 days prior to first use. • Unpunctured vials may be stored between 8° to 25°C (46° to 77°F) for up to 12 hours. • Do not refreeze once thawed.	• Prior to dilution, store at -80°C to -60°C (-112°F to -76°F). • After dilution, store the vaccine at 2°C to 25°C (35°F to 77°F). • Discard after 6 hours.	• The vials should be protected from light. • Unpunctured vials may be stored between 9°C to 25°C (47°F to 77°F) for up to 12 hours. • After the first dose has been withdrawn, the vial should be held between 2° to 8°C (36° to 46°F) for up to 6 hours or at room temperature (maximally 25°C/77°F) for up to 2 hours. • The vial should be discarded if the vaccine is not used within these times.
PI date	12/2020	5/2021	3/2021

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Moderna

Pfizer-BioNTech

Janssen