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Components of
Pneumococcal Vaccine

Excipients Table
Allergens Table
Components Table

 

Indication

Immunity in infants and children against S. pneumoniae

Proprietary Name

Prevnar

Prevnar-13

Pneumovax 23

Manufacturers

Wyeth

Wyeth

Merck

Viability

Inactivated

 

Inactivated

Microorganism

Streptococcus pneumoniae 7-valent serotype

Streptococcus pneumoniae 13-valent serotype

Streptococcus pneumoniae
23-valent serotype
Indicated Ages   6 wks - 17 yrs and 50+ yrs  

Pediatric Dose

0.5 mL

6 wk - 17 yr : 0.5 mL

0.5 mL

Adult Dose

  50 and older: 0.5 mL  

Route

Intramuscular

Intramuscular

Intramuscular or Subcutaneous

Dose form

Suspension

 

Solution

Appearance

Homogeneous, white suspension

Homogeneous, white suspension

Clear, colorless solution

Concentration (per 0.5 mL)

Serotypes 4, 9V, 14, 18C, 19F, and 23F, 2 mcg each

Serotypes 6B, 4 mcg

Serotypes s 1, 3, 4, 5, 6A, 7F, 9V, 14, 18C, 19A, 19F, 23F, 2.2 mcg each

Serotypes 6B, 4.4 mcg

23 polysaccharides, 25 mcg for each (1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19F, 19A, 20, 22F, 23F, 33F)

Excipients

None   None

Adjuvants

Diphtheria CRM197, 20 mcg
Aluminum phosphate, 0.125 mg

CRM197 carrier protein, 34 mcg
Polysorbate 80, 100 mcg
Succinate buffer, 295 mcg 
Aluminum phosphate, 125 mcg

None

Allergens

Dry natural rubber   None

Preservatives

None

 

Phenol, 0.25%

Media

Soy peptone broth   Bovine proteins and other macromolecular components

Packaging

Vial, 1 dose (5 per package)   Vials, 5-dose, 10 5-dose vials, 10 single-dose vial

Routine storage

2 to 8 C (35-46 F)

Do not freeze

 

2 to 8 C (35-46 F)

Do not freeze

Package Insert last updated   01/2013  

updated Feb 2013

This page was last updated on February 12, 2014

2014 Institute for Vaccine Safety