Components of

MMR/MMRV Vaccines

Components Page
Excipients Table
Allergens Table
       
  MMR MMRV
Name MMR II ProQuad
Manufacturer Merck Sharp & Dohme Corp Merck Sharp & Dohme Corp
Viability Live, attenuated Live, attenuated
Indicated Ages 12 months or older 12 mos - 12 yrs
Dose 0.5 mL 0.5 mL
Schedule Dose 1: 12-15 mos, Dose 2: 4-6 yrs Dose 1: 12-15 mos, Dose 2: 4-6 yrs
Route Subcutaneous Subcutaneous
Appearance Clear yellow after reconstitution Clear yellow after reconstitution
Concentration Measles virus, ≥1000 TCID50
Mumps virus, ≥12,500 TCID50
Rubella virus, ≥1000 TCID50
Measles virus, ≥3.00 log10 TCID50
Mumps virus, ≥4.30 log10 TCID50
Rubella virus, ≥3.00 log10TCID50
Varicella virus, ≥3.99 log10PFU
Preservative None None
Adjuvant None None
Excipients • Sorbitol, 14.5 mg
• Sodium phosphate, amt not specified
• Sucrose, 1.9 mg
• Sodium chloride, amt not specified
• Hydrolyzed gelatin, 14.5 mg
• Recombinant human albumin, ≤0.3 mg
• Fetal bovine serum, <1 ppm
• Other buffer and media ingredients, amt not specified
• Neomycin, ~25 mcg
• Sucrose, 21 mg
• Hydrolyzed gelatin, 11 mg
• Sodium chloride, 2.4 mg
Sorbitol, 1.8 mg
• Monosodium L-glutamate, 0.40 mg
• Sodium phosphate dibasic, 0.34 mg
• Human albumin, 0.31 mg
• Sodium bicarbonate, 0.17 mg
• Potassium phosphate monobasic, 72 mcg
• Potassium chloride, 60 mcg
• Potassium phosphate dibasic, 36 mcg
• MRC-5 cells, residual components
• DNA, residual components
• Protein, residual components
• Neomycin, <16 mcg
• Bovine calf serum, 0.5 mcg
• Other buffer and media ingredients, amts not specified
Allergens • Gelatin, 14.5 mg
• Neomycin, 25 mcg
• Gelatin, 11 mg
• Neomycin,
Media Measles and Mumps:
• Chick embryo cell culture
• Medium 199
Rubella:
• Minimum Essential Medium (MEM)
Measles and Mumps:
• Chick embryo cell culture
Rubella Viruses:
WI-38 human diploid lung fibroblasts
Varicella Virus:

MRC-5 cells
Packaging • 10-pack of single-dose vials
• 25-pack of single dose tubes
10-packs of diluent vials
Storage 2-8C (36-46F)
Do not freeze
2-8C (35-46F)
Do not freeze
PI date May 2017 April 2016
    table last updated 10/31/17