Components of

2017-18 Influenza Vaccines: Trivalent

Components Page
Excipients Table
Allergens Table
         
Name Afluria Fluad Flublok Fluvirin
Manufacturer Seqirus Sequis Protein Sciences Seqirus
Viability Inactivated Inactivated Inactivated
Indicated Ages 5 years and older 65 years and older 18 years and older 4 years and older
Dose 0.5 mL 0.5 mL 0.5 mL 0.5 mL
Schedule 1 dose (for 5-8 year olds, 1 or 2 doses depends on vaccination history as per ACIP annual recommendations 1 dose 1 dose 1 dose (for 4-8 year olds, 1 or 2 doses depends on vaccination history as per ACIP annual recommendations
Route Intramuscular Intramuscular Intramuscular - prefer deltoid muscle Intramuscular
Appearance Colorless to slightly opalescent Milky while Clear and colorless Slightly opalescent
Concentration • A/Singapore/GP1908/2015 (H1N1) IVR-180A, 15 mcg HA
• A/Hong Kong/4801/2014 (NYMC X-263B, A/Hong Kong/4801/2014 (H3N2) – like), 15 mcg HA
• B/Brisbane/46/2015, 15 mcg HA
• A/Singapore/GP1908/2015, IVR-180 (H1N1) (an A/Michigan/45/2015 (H1N1)pdm09-like virus), 15 mcg HA
• A/Hong Kong/4801/2014 (H3N2) NYMC X-263B, 15 mcg HA
• B/Brisbane/60/2008, wild type (a B/Brisbane/60/2008-like virus), 15 mcg HA
• A/Michigan/45/2015 (H1N1), 45 mcg HA
• A/Hong Kong/4801/2014 (H3N2), 45 mcg HA
• B/Brisbane/60/2008, 45 mcg HA
• A/Singapore/GP1908/2015, IVR-180 (an A/Michigan/45/2015 (H1N1)pdm09-like virus, 15 mcg HA
• A/Hong Kong/4801/2014, NYMC X-263B (H3N2) (an A/Hong Kong/4801/2014-like virus), 15 mcg HA
• B/Brisbane/60/2008, wild type (a B/Brisbane/60/2008-like virus), 15 mcg HA
Preservative Thimerosal, 25 mcg mercury in multi-dose vial
Single-dose: preservative free
None None Thimerosal, ≤ 1 mcg mercury in single dose syringe; 25 mcg mercury in multi-dose vial
Adjuvant None MF59C.1, 9.75 mg squalene None None
Excipients • Sodium chloride, 4.1 mg
• Dibasic sodium phosphate, 300 mcg
• Monobasic sodium phosphate, 80 mcg
• Potassium chloride, 20 mcg
• Monobasic potassium phosphate, 20 mcg
• Calcium chloride, 0.5 mcg

May also contain trace amounts of:
• Sodium taurodeoxycholate, ≤10 ppm
• Ovalbumin, <1 mcg
• Sucrose, <10 mcg
• Neomycin sulfate, <61.8 ng
• Polymyxin B, <10.5 ng
• Beta-propiolactone, <2 ng
• Polysorbate 80 (Tween 80), 1.175 mg
• Sorbitan trioleate, 1.175 mg
• Sodium citrate dihydrate, 0.66 mg
• Citric acid monohydrate, 0.04 mg

May also contain residual amounts of:
• Neomycin, ≤0.02 mcg
• Kanamycin, ≤0.03 mcg
• Barium, <0.5 mcg
• Residual egg proteins, <0.4 mcg
• Formaldehyde, ≤10 mcg or
• CTAB, ≤12 mcg
• Sodium chloride, 4.4 mg
• Monobasic sodium phosphate, 0.195 mcg
• Dibasic sodium phosphate, 1.3 mg
• Polysorbate 20 (Tween®20), 27.5 mcg

May also contain residual amounts:
• Baculovirus and Spodoptera frugiperda cell proteins, ≤ 14.3 mcg
• Baculovirus and cellular DNA, ≤10 ng
• Triton X-100, ≤100 mcg
May contain residual amounts of:
• Egg proteins, ≤1 mcg ovalbumin
• Polymyxin, ≤3.75 mcg
• Neomycin, ≤2.5 mcg
• Beta-propiolactone, ≤0.5 mcg
• Nonylphenol ethoxylate, ≤0.015% w/v
Allergens • Sodium taurodeoxycholate, ≤10 ppm
• Ovalbumin, <1 mcg
• Neomycin sulfate, <61.8 ng
• Polymyxin B, <10.5 ng
• Thimerosal, 24.5 mcg in multi-dose only
• Neomycin, ≤0.02 mcg
• Residual egg proteins, <0.4 mcg
• Latex, tip caps of the prefilled syringes contain natural rubber latex
None None
Media Allantoic fluid of embryonated chicken eggs Embryonated hens' eggs Serum-free medium composed of chemically-defined lipids, vitamins, amino acids, and mineral salts Embryonated hens' eggs
Packaging Pre-filled syringe and Multi-dose vial Pre-filled syringes in package of 10 and Pre-filled single syringe Single-dose prefilled syringe Pre-filled syringe and Multi-dose vial
Storage 2 to 8° C (36-46° F)
Do not freeze
2 to 8° C (36-46° F)
Do not freeze
2 to 8° C (36-46° F)
Do not freeze
2 to 8° C (36-46° F)
Do not freeze
PI date March 2017 March 2017 March 2017 March 2017
        table last updated 10/18/17