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Institute for Vaccine Safety

Johns Hopkins Bloomberg School of Public Health

615 N. Wolfe Street

Room W5041

Baltimore, MD 21205

www.vaccinesafety.edu

 

 

Allergens per 0.5 mL 

Excipients Table
Components Table

Amphotericin B

RabAvert (Novartis)

Rabies

<2 ng

Casein, Bovine

Boostrix (GSK)

Tdap

Ingredient in Latham medium

 

Infanrix (GSK)

DTaP

12.2-18.3 ng/mL (Ingredient in Latham medium)

 

Kinrix (GSK)

DTaP+IPV

Ingredient in Latham medium

 

Pediarix (GSK)

DTaP+HepB+IPV

Ingredient of Latham medium

 

Vivotif (Berna)

Typhoid

in medium

Chlortetracyclin

RabAvert (Novartis)

Rabies

<20 ng

Egg

Afluria (CSL)

Influenza

≤1 mcg

 

Agriflu (Novartis)

Influenza

<0.4 mcg

 

Fluarix (GSK)

Influenza

≤0.05 mcg

 

FluLaval (GSK)

Influenza

≤1 mcg

 

Flumist (MedImmune)

Influenza

residual

 

Fluvirin (Novartis)

Influenza

≤1 mcg

 

Fluzone (sp)

Influenza

residual

 

MMR II (Merck)

MMR

residual

 

ProQuad (Merck)

MMR+varicella

residual

 

RabAvert (Chiron)

Rabies

<3 ng/dose (per 1 mL dose)

 

YF-Vax (sp)

Yellow Fever

residual

Gelatin (Bovine)

RabAvert (Novartis)

Rabies

<12 mg (Polygeline)

Gelatin (Porcine)

Flumist (MedImmune)

Influenza

Hydrolyzed Gelatin, 2.00 mg/0.2mL dose

 [click here for information from religious leaders on on use of these vaccines] 

Fluzone (sp)

Influenza

0.05% in 0.25 mL and 0.5 mL dose

JE-Vax

Japanese Encephalitis

500 mcg (per 1 mL dose)

MMR II (Merck)

MMR

Hydrolyzed Gelatin, 14.5 mg

 

ProQuad (Merck)

MMR+varicella

Hydrolyzed Gelatin, 11 mg

 

Tripedia (sp)

DTaP

Residual used in the production of the pertussis concentrate.

 

Varivax (Merck)

Varicella

Hydrolyzed Gelatin, 12.5 mg

 

YF-Vax (sp)

Yellow Fever

as stabilizer

 

Zostavax (Merck)

Varicella Zoster

Hydrolyzed gelatin, 15.58 mg

Gentamicin Sulfate

Flumist (MedImmune)

Influenza

<0.015 mcg/mL

 

Fluarix (GSK)

Influenza

≤0.15 mcg

Latex

ActHIB (AP)

Hib

The stopper of the diluent vial contains dry natural latex rubber.

Agriflu (Novartis)

Influenza

Tip caps of syringes may contain natural rubber latex.

Biothrax (Emergent)

Anthrax

Vial stopper contains dry natural rubber.

 

Boostrix (GSK)

Tdap

One type of prefilled syringe has a tip cap which may contain natural rubber latex and a plunger which does not contain latex. The other type has a tip cap and a rubber plunger which contain dry natural latex rubber.

 

Cervarix (GSK)

HPV

One type of prefilled syringe has a tip cap which may contain natural rubber latex. The other type has a tip cap and a rubber plunger which contain dry natural latex rubber.

 

Comvax (Merck)

Hib-HepB

Vial stopper contains dry natural latex rubber.

 

DT (AP)

DT

Stopper to the vial contains dry natural latex rubber.

 

Engerix-B (GSK)

Hep B

One type of prefilled syringe has a tip cap which may contain natural rubber latex. The other type has a tip cap and a rubber plunger which contain dry natural latex rubber.

 

Fluarix (GSK)

Influenza

Tip caps of the prefilled syringes may contain natural rubber latex.

 

Fluvirin (Novartis)

Influenza

Tip caps of the prefilled syringes may contain natural rubber latex.

 

Fluzone (sp)

Influenza

Prefilled syringe tip caps of Fluzone and Fluzone High-Dose may contain natural rubber latex.

 

Havrix (GSK)

Hep A

One type of prefilled syringe has a tip cap which may contain natural rubber latex. The other type has a tip cap and a rubber plunger which contain dry natural latex rubber.

Hiberix (GSK)

Hib

Tip caps of the prefilled syringes may contain natural rubber latex.

 

Infanrix (GSK)

DTaP

One type of prefilled syringe has a tip cap which may contain natural rubber latex and a plunger which does not contain latex. The other type has a tip cap and a rubber plunger which contain dry natural latex rubber.

 

Kinrix (GSK)

DTaP/IPV

One type of prefilled syringe has a tip cap which may contain natural rubber latex. The other type has a tip cap and a rubber plunger which contain dry natural latex rubber.

 

MENOMUNE (sp)

Meningococcal

The stoppers to the vials of lyophilized vaccine and diluent contain dry natural latex rubber.

 

Pediarix (GSK)

DTaP-HepB-IPV

One type of prefilled syringe has a tip cap which may contain natural rubber latex. The other type has a tip cap and a rubber plunger which contain dry natural latex rubber.

 

PedvaxHIB (Merck)

Hib

 Vial stopper contains dry natural latex rubber.

 

Recombivax HB (Merck)

Hep B

Vial stopper and the syringe plunger stopper and tip cap contain dry natural latex rubber.

 

Rotarix (GSK)

Rotaviris

One type of prefilled applicator has a tip cap which may contain natural rubber latex. The other type has both a tip cap and a rubber plunger which contain dry natural latex rubber.

 

TriHIBit (sp)

DTaP-Hib

Stopper of the vial contains dry natural latex rubber.

 

Tripedia (sp)

DTaP

Stopper of the vial contains dry natural latex rubber.

 

Twinrix (GSK)

Hep AB

One type of prefilled syringe has a tip cap which may contain natural rubber latex. The other type has a tip cap and a rubber plunger which contain dry natural latex rubber.

 

Vaqta (Merck)

Hepatitis A

Vial stopper and syringe plunger stopper and tip cap contain dry natural latex rubber.

 

YF-Vax (sp)

Yellow Fever

Stopper of the vial contains dry natural latex rubber.

Neomycin

ACAM2000 (sp)

Smallpox

trace amounts

 

Afluria (CSL)

Influenza

≤3 ng (Neomycin sulfate)

 

Agriflu (Novartis)

Influenza

≤0.02 mcg

 

Fluvirin (Novartis)

Influenza

≤2.5 mcg

 

Havrix (GSK)

Hep A

≤40 ng/mL (Neomycin sulfate)

 

Imovax Rabies (sp)

Rabies

<150 mcg (Neomycin Sulfate)

 

IPOL (sp)

Polio

<5 ng [.005 mcg]

 

Kinrix (GSK)

DTaP/IPV

≤0.05 ng [5.0 × 10-5 mcg]

 

MMR II (Merck)

MMR

25 mcg

 

Pediarix (GSK)

DTaP-HepB-IPV

≤0.05 ng [5.0 × 10-5 mcg]

 

Pentacel (sp)

DTaP-IPV-Hib

<4 pg [4.0 × 10-6 mcg]

 

ProQuad (Merck)

MMR+Varicella

<16 mcg

 

RabAvert (Chiron)

Rabies

< 1 mcg

 

Twinrix (GSK)

Hep AB

≤20 ng (neomycin sulfate)

 

Vaqta (Merck)

Hepatitis A

<10 ppb

 

Varivax (Merck)

Varicella

trace amounts

 

Zostavax (Merck)

Varicella Zoster

trace amounts

Ovalbumin

Afluria (CSL)

Influenza

≤ 1 mcg

 

Fluarix (GSK)

Influenza

≤ 0.05 mcg

 

FluLaval (sp)

Influenza

≤1 mcg

 

Fluvirin (Novartis)

Influenza

≤1 mcg

 

RabAvert (Novartis)

Rabies

< 3 ng [0.003 mcg]

Polymyxin B

ACAM2000 (sp)

Smallpox

trace amounts

 

Afluria (CSL)

Influenza

≤0.5 ng

 

Fluvirin (Novartis)

Influenza

≤3.75 mcg

 

IPOL (sp)

Polio

25 ng [0.025 mcg]

 

Kinrix (GSK)

DTaP/IPV

≤0.01 ng [1.0 × 10-5 mcg]

 

Pediarix (GSK)

DTaP-HepB-IPV

≤0.01 ng [1.0 × 10-5 mcg]

 

Pentacel (sp)

DTaP-IPV-Hib

<4 pg [4.0 × 10-6 mcg] (polymyxin B sulfate)

 Serum, Fetal Bovine

IPOL (sp)

Polio

<1 ppm

 

MMR II (Merck)

MMR

<1 ppm

 

ProQuad (Merck)

MMR+varicella

0.5 mcg

 

RotaTeq (Merck)

Rotavirus

trace amounts

 

Varivax (Merck)

Varicella

trace amounts

 

Zostavax (Merck)

Varicella Zoster

trace amounts (bovine calf serum)

Sodium taurodeoxycholate

Afluria (CSL)

Influenza

<10 ppm

Streptomycin

IPOL (sp)

Polio

<200 ng [0.2 mcg]

Thimerosal

ActHIB (AP)

Hib

≤0.3 mcg

Afluria (CSL)

Influenza

24.5 mcg mercury in multi-dose vial

 

Decavac (sp)

Td

≤0.3 mcg mercury

 

DT (sp)

DT

≤0.3 mcg mercury

 

FluLaval (GSK)

Influenza

25 mcg mercury

 

Fluvirin (Novartis)

Influenza

≤1 mcg in prefilled syringe;25 mcg mercury per dose in multi-dose vial

 

Fluzone (sp)

Influenza

25 mcg mercury in multi-dose vial

 

JE-Vax (sp)

Japanese Encephalitis

0.007%

 

MENOMUNE (sp)

Meningococcal

25 mcg mercury in multi-dose diluent

 

Td Adsorbed (Aventis)

Tetanus Toxoid Adsorbed

≤0.3 mcg mercury

 

TriHIBit (sp)

Hib

trace amounts

 

Tripedia (sp)

DTaP

≤0.3 mcg mercury

Yeast

Comvax (Merck)

Hib-HepB

No detectable yeast DNA; ≤1% yeast protein

 

Engerix-B (GSK)

Hep B

5% yeast protein

 

Gardasil (Merck)

HPV

<7 mcg yeast protein/dose

 

Menveo (Novartis)

Meningococcal

"...CY medium containing yeast extracts ..."

 

Pediarix (GSK)

Hep B

≤5% yeast protein

 

Prevnar (WL)

Pneumococcal

"…and yeast extract-based medium"

 

Recombivax HB (Merck)

Hep B

≤1% yeast protein

 

Twinrix (GSK)

Hep AB

≤5% yeast protein

 

Vivotif Berna (Berna)

Typhoid

yeast extract from media

updated February 21, 2013

This page was last updated on April 05, 2013

© 2013 Institute for Vaccine Safety