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Institute for Vaccine Safety

Johns Hopkins Bloomberg School of Public Health

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Allergens per 0.5 mL 

Excipients Table
Components Table

Amphotericin B

RabAvert (Novartis)

Rabies

<2 ng

Casein, Bovine

Boostrix (GSK)

Tdap

Ingredient in Latham medium

 

Infanrix (GSK)

DTaP

12.2-18.3 ng/mL (Ingredient in Latham medium)

 

Kinrix (GSK)

DTaP+IPV

Ingredient in Latham medium

 

Menomune (sp)

Meningococcal

Ingredient of medium

 

Pediarix (GSK)

DTaP+HepB+IPV

Ingredient of Latham medium

 

Vivotif (Berna)

Typhoid

Ingredient in medium

Chlortetracyclin

RabAvert (Novartis)

Rabies

<20 ng

Egg

Afluria (CSL)

Influenza

≤1 mcg ovalbumin

 

Agriflu (Novartis)

Influenza

<0.4 mcg egg proteins

 

Fluarix (GSK)

Influenza

≤0.05 mcg ovalbumin (Trivalent and Quadrivalent)

 

FluLaval (GSK)

Influenza

≤0.3 mcg ovalbumin (Trivalent and Quadrivalent)

 

Flumist Quad (MedImmune)

Influenza

<0.24 mcg ovalbumin

 

Fluvirin (Novartis)

Influenza

≤1 mcg ovalbumin

 

Fluzone (sp)

Influenza

residual (all formulas)

 

MMR II (Merck)

MMR

residual

 

ProQuad (Merck)

MMR+varicella

residual

 

RabAvert (Chiron)

Rabies

<3 ng/1 mL dose ovalbumin

 

YF-Vax (sp)

Yellow Fever

residual

Gelatin (Bovine)

RabAvert (Novartis)

Rabies

<12 mg polygeline

Gelatin (Porcine)

Flumist Quad (MedImmune)

Influenza

2.00 mg/0.2mL dose hydrolyzed gelatin

 [click here for information from religious leaders on on use of these vaccines] 

Fluzone (sp)

Influenza

0.05% in 0.25 mL and 0.5 mL dose (Trivalent only)

JE-Vax

Japanese Encephalitis

500 mcg (per 1 mL dose)

MMR II (Merck)

MMR

14.5 mg hydrolyzed gelatin

 

ProQuad (Merck)

MMR+varicella

11 mg hydrolyzed gelatin

 

Varivax (Merck)

Varicella

12.5 mg hydrolyzed gelatin

 

YF-Vax (sp)

Yellow Fever

as stabilizer

 

Zostavax (Merck)

Varicella Zoster

15.58 mg hydrolyzed gelatin

Gentamicin Sulfate

Fluarix (GSK)

Influenza

<0.15 mcg

 

Flumist Quad (MedImmune)

Influenza

≤0.15 mcg/mL

Latex

ActHIB (AP)

Hib

Diluent vial stopper contains dry natural latex rubber

 

Adacel (sp)

Tdap

Prefilled syringe tip caps may contain natural rubber latex

Agriflu (Novartis)

Influenza

Prefilled syringe tip caps may contain natural rubber latex

Biothrax (Emergent)

Anthrax

Vial stopper contains dry natural rubber

 

Boostrix (GSK)

Tdap

One type of prefilled syringe tip cap may contain natural rubber latex. The other type has a tip cap and a rubber plunger which contain dry natural latex rubber

 

Cervarix (GSK)

HPV

One type of prefilled syringe tip cap may contain natural rubber latex. The other type has a tip cap and a rubber plunger which contain dry natural latex rubber

 

Comvax (Merck)

Hib-HepB

Vial stopper contains dry natural latex rubber

 

DT (AP)

DT

Stopper to the vial contains dry natural latex rubber

 

Engerix-B (GSK)

Hep B

One type of prefilled syringe tip cap may contain natural rubber latex. The other type has a tip cap and a rubber plunger which contain dry natural latex rubber

 

Fluarix (GSK)

Influenza

Prefilled syringe tip caps may contain natural rubber latex (Trivalent and Quadrivalent)

 

Flucelvax (Novartis)

Influenza

Tip caps of the prefilled syringes may contain natural rubber latex

 

Fluvirin (Novartis)

Influenza

Tip caps of the prefilled syringes may contain natural rubber latex

 

Havrix (GSK)

Hep A

One type of prefilled syringe tip cap may contain natural rubber latex. The other type has a tip cap and a rubber plunger which contain dry natural latex rubber

Hiberix (GSK)

Hib

Tip caps of the prefilled syringes may contain natural rubber latex

 

Infanrix (GSK)

DTaP

One type of prefilled syringe may contain natural rubber latex. The other type has a tip cap and a rubber plunger which contain dry natural latex rubber

 

Kinrix (GSK)

DTaP/IPV

One type of prefilled syringe may contain natural rubber latex. The other type has a tip cap and a rubber plunger which contain dry natural latex rubber

 

Menomune (sp)

Meningococcal

Vial stoppers to lyophilized vaccine and diluent contain dry natural latex rubber

 

Pediarix (GSK)

DTaP-HepB-IPV

One type of prefilled syringe may contain natural rubber latex. The other type has a tip cap and a rubber plunger which contain dry natural latex rubber

 

PedvaxHIB (Merck)

Hib

Vial stopper contains dry natural latex rubber

 

Recombivax HB (Merck)

Hep B

Vial stopper and syringe plunger stopper and tip cap contain dry natural latex rubber

 

Rotarix (GSK)

Rotaviris

One type of prefilled syringe may contain natural rubber latex. The other type has a tip cap and a rubber plunger which contain dry natural latex rubber

 

Tenivac (sp)

Td

Stopper of the vial may contain dry natural latex rubber

 

TriHIBit (sp)

DTaP-Hib

Stopper of the vial contains dry natural latex rubber.

 

Twinrix (GSK)

Hep AB

One type of prefilled syringe may contain natural rubber latex. The other type has a tip cap and a rubber plunger which contain dry natural latex rubber

 

Vaqta (Merck)

Hepatitis A

Vial stopper and syringe plunger stopper and tip cap contain dry natural latex rubber

 

YF-Vax (sp)

Yellow Fever

Stopper of the vial contains dry natural latex rubber

Neomycin

ACAM2000 (sp)

Smallpox

trace amounts

 

Afluria (CSL)

Influenza

≤3 ng neomycin sulfate

 

Agriflu (Novartis)

Influenza

≤0.02 mcg

 

Fluvirin (Novartis)

Influenza

≤2.5 mcg

 

Havrix (GSK)

Hep A

≤40 ng/mL neomycin sulfate

 

Imovax Rabies (sp)

Rabies

<150 mcg neomycin sulfate

 

IPOL (sp)

Polio

<5 ng [.005 mcg]

 

Kinrix (GSK)

DTaP/IPV

≤0.05 ng [5.0 × 10-5 mcg]

 

MMR II (Merck)

MMR

25 mcg

 

Pediarix (GSK)

DTaP-HepB-IPV

≤0.05 ng [5.0 × 10-5 mcg]

 

Pentacel (sp)

DTaP-IPV-Hib

<4 pg [4.0 × 10-6 mcg]

 

ProQuad (Merck)

MMR+Varicella

<16 mcg

 

RabAvert (Chiron)

Rabies

< 1 mcg

 

Twinrix (GSK)

Hep AB

≤20 ng neomycin sulfate

 

Vaqta (Merck)

Hepatitis A

<10 ppb (parts per billion)

 

Varivax (Merck)

Varicella

trace amounts

 

Zostavax (Merck)

Varicella Zoster

trace amounts

Ovalbumin

see Egg

   

Polymyxin B

ACAM2000 (sp)

Smallpox

trace amounts

 

Afluria (CSL)

Influenza

≤0.5 ng

 

Fluvirin (Novartis)

Influenza

≤3.75 mcg

 

IPOL (sp)

Polio

25 ng [0.025 mcg]

 

Kinrix (GSK)

DTaP/IPV

≤0.01 ng [1.0 × 10-5 mcg]

 

Pediarix (GSK)

DTaP-HepB-IPV

≤0.01 ng [1.0 × 10-5 mcg]

 

Pentacel (sp)

DTaP-IPV-Hib

<4 pg [4.0 × 10-6 mcg] polymyxin B sulfate

 Serum, Fetal Bovine

IPOL (sp)

Polio

<1 ppm

 

MMR II (Merck)

MMR

<1 ppm

 

ProQuad (Merck)

MMR+varicella

0.5 mcg bovine calf serum

 

RotaTeq (Merck)

Rotavirus

trace amounts

 

Varivax (Merck)

Varicella

trace quantities

 

Zostavax (Merck)

Varicella Zoster

trace amounts bovine calf serum

Sodium taurodeoxycholate

Afluria (CSL)

Influenza

<10 ppm

Streptomycin

IPOL (sp)

Polio

<200 ng [0.2 mcg]

Thimerosal

ActHIB (AP)

Hib

≤0.3 mcg

Afluria (CSL)

Influenza

24.5 mcg mercury (multi-dose vial)

 

DT (sp)

DT

≤0.3 mcg mercury

 

FluLaval (GSK)

Influenza

<25 mcg mercury

 

Fluvirin (Novartis)

Influenza

≤1 mcg mercury (prefilled syringe);25 mcg mercury (multi-dose vial)

 

Fluzone (sp)

Influenza

25 mcg mercury (multi-dose vial only)

 

JE-Vax (sp)

Japanese Encephalitis

0.007%

 

Menomune (sp)

Meningococcal

25 mcg mercury (multi-dose diluent)

 

Td Adsorbed (Aventis)

Tetanus Toxoid Adsorbed

≤0.3 mcg mercury

Yeast

Comvax (Merck)

Hib-HepB

No detectable yeast DNA; ≤1% yeast protein

 

Engerix-B (GSK)

Hep B

5% yeast protein

 

Gardasil (Merck)

HPV

<7 mcg yeast protein

 

Menveo (Novartis)

Meningococcal

"...CY medium containing yeast extracts ..."

 

Pediarix (GSK)

Hep B

≤5% yeast protein

 

Prevnar (WL)

Pneumococcal

"…and yeast extract-based medium"

 

Recombivax HB (Merck)

Hep B

<1% yeast protein

 

Twinrix (GSK)

Hep AB

≤5% yeast protein

 

Vivotif Berna (Berna)

Typhoid

yeast extract from media

updated November 13, 2013

This page was last updated on November 13, 2013

© 2014 Institute for Vaccine Safety